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Editorial
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Volume 336:950-952 March 27, 1997 Number 13
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Is Atrial Fibrillation Sometimes a Genetic Disease?

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In their article in this issue of the Journal, Brugada and coworkers1 describe three families, all from the same region in northern Spain, in which 21 of 49 family members had atrial fibrillation. Two died of cerebrovascular accidents at 36 and 68 years of age. Of the 19 living family members, 18 had chronic atrial fibrillation, whereas 1 had paroxysmal atrial fibrillation. In none of these patients could a specific cause of atrial fibrillation, such as hypertension, valvular disease, or hyperthyroidism, be found. The age at diagnosis ranged from 2 to 46 years in the three families. Comparison of pooled . . . [Full Text of this Article]

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