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Correspondence
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Volume 336:961-962 March 27, 1997 Number 13
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The Effect of Pravastatin on Coronary Events after Myocardial Infarction

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 by Sacks, F. M.
To the Editor: The long-awaited results of the Cholesterol and Recurrent Events (CARE) trial (Oct. 3 issue)1 confirm and extend the results of the virtually unbroken string of coronary disease prevention trials demonstrating the efficacy of substantial reductions in low-density lipoprotein (LDL) cholesterol in preventing coronary heart disease (notably with respect to secondary prevention). Since the reduction in risk in this study was proportional to base-line levels of LDL cholesterol, with benefit being confined to patients with higher pretreatment LDL levels (who were therefore at higher risk), even if the levels fell within the normal range, these findings are both . . . [Full Text of this Article]

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