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Previous Volume 336:964-965 March 27, 1997 Number 13 Next

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To the Editor: Hydroxyurea has been used in the treatment of sickle cell anemia to elevate hemoglobin levels and reduce clinical complications.¹ The potential usefulness of hydroxyurea in the thalassemia syndromes is considerably less clear.^1,2 In patients with -thalassemia intermedia, the hematologic response to hydroxyurea alone or in combination with recombinant human erythropoietin is controversial,^3,4,5 and little is known about the effectiveness of long-term therapy. The standard therapeutic approach to -thalassemia major still relies on regular blood transfusions and the use of iron chelators. In this report, we describe the clinical and hematologic response of a 20-year-old man with transfusion-dependent ⁰. . . [Full Text of this Article]

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