FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 336:999-1007 April 3, 1997 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Glatt, A. E. PubMed Citation

Known since antiquity,¹ osteomyelitis is a difficult-to-treat infection characterized by the progressive inflammatory destruction and new apposition of bone.^2,3,4 This review focuses on current knowledge of the disease and the progress being made in understanding its pathogenesis, diagnosis, and treatment.

Pathogenesis

The pathogenesis of osteomyelitis has been explored in various animal models⁵; these studies have found that normal bone is highly resistant to infection, which can only occur as a result of very large inocula, trauma, or the presence of foreign bodies.^6,7 Certain major causes of infection, such as Staphylococcus aureus, adhere to bone by expressing receptors (adhesins) for components . . . [Full Text of this Article]

Clinical Features and Microbiologic and Radiologic Diagnosis

Hematogenous Osteomyelitis

Osteomyelitis Due to a Contiguous Focus of Infection

Osteomyelitis Due to Vascular Insufficiency

Antibiotic Prophylaxis in Bone Surgery

Treatment

Basic Principles

Surgical Management

Specific Conditions

Conclusions

Source Information

From the Division of Infectious Diseases and Medical Clinic II, Department of Medicine, Geneva University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland, where reprint requests should be addressed to Dr. Lew.

References

Related Letters:

Osteomyelitis
Glatt A. E., Shea K. W., Lew D. P., Waldvogel F.
Extract | Full Text  
N Engl J Med 1997; 337:428-429, Aug 7, 1997. Correspondence

This article has been cited by other articles:

• Adeyemi, O. A., Qi, C., Zembower, T. R., Ison, M. G., Grant, T. H., Hartigan, B. J., Malczynski, M., Stosor, V. (2008). Invasive Infections with Community-Associated Methicillin-Resistant Staphylococcus aureus after Kidney Transplantation. J. Clin. Microbiol. 46: 2809-2813 [Abstract] [Full Text]  
• Butalia, S., Palda, V. A., Sargeant, R. J., Detsky, A. S., Mourad, O. (2008). Does This Patient With Diabetes Have Osteomyelitis of the Lower Extremity?. JAMA 299: 806-813 [Abstract] [Full Text]  
• Ballani, N. S., Al-Huda, F. A., Khan, H. A., Al-Mohannadi, S., Mahmood, H., Al-Enezi, F. (2007). The Value of Quantitative Uptake of 99mTc-MDP and 99mTc-HMPAO White Blood Cells in Detecting Osteomyelitis in Violated Peripheral Bones. J. Nucl. Med. Technol. 35: 91-95 [Abstract] [Full Text]  
• Ruebner, R., Keren, R., Coffin, S., Chu, J., Horn, D., Zaoutis, T. E. (2006). Complications of Central Venous Catheters Used for the Treatment of Acute Hematogenous Osteomyelitis. Pediatrics 117: 1210-1215 [Abstract] [Full Text]  
• Uckay, I., Assal, M., Legout, L., Rohner, P., Stern, R., Lew, D., Hoffmeyer, P., Bernard, L. (2006). Recurrent Osteomyelitis Caused by Infection with Different Bacterial Strains without Obvious Source of Reinfection.. J. Clin. Microbiol. 44: 1194-1196 [Abstract] [Full Text]  
• Rouse, M. S., Piper, K. E., Jacobson, M., Jacofsky, D. J., Steckelberg, J. M., Patel, R. (2006). Daptomycin treatment of Staphylococcus aureus experimental chronic osteomyelitis. J Antimicrob Chemother 57: 301-305 [Abstract] [Full Text]  
• Zuluaga, A. F., Galvis, W., Saldarriaga, J. G., Agudelo, M., Salazar, B. E., Vesga, O. (2006). Etiologic Diagnosis of Chronic Osteomyelitis: A Prospective Study. Arch Intern Med 166: 95-100 [Abstract] [Full Text]  
• Marriott, I., Rati, D. M., McCall, S. H., Tranguch, S. L. (2005). Induction of Nod1 and Nod2 Intracellular Pattern Recognition Receptors in Murine Osteoblasts following Bacterial Challenge. Infect. Immun. 73: 2967-2973 [Abstract] [Full Text]  
• Ida, M, Watanabe, H, Tetsumura, A, Kurabayashi, T (2005). CT findings as a significant predictive factor for the curability of mandibular osteomyelitis: multivariate analysis. Dentomaxillofac Radiol 34: 86-90 [Abstract] [Full Text]  
• Haase, K. K., McCracken, K. A., Akins, R. L. (2005). Catheter-Related Bloodstream Infections in the Intensive Care Unit Population. Journal of Pharmacy Practice 18: 42-52 [Abstract]  
• Zimmerli, W., Trampuz, A., Ochsner, P. E. (2004). Prosthetic-Joint Infections. NEJM 351: 1645-1654 [Full Text]  
• Senneville, E., Legout, L., Valette, M., Yazdanpanah, Y., Giraud, F., Beltrand, E., Obert, G., Dubreuil, L., Migaud, H., Mouton, Y. (2004). Risk factors for anaemia in patients on prolonged linezolid therapy for chronic osteomyelitis: a case-control study. J Antimicrob Chemother 54: 798-802 [Abstract] [Full Text]  
• Lazzarini, L., Mader, J. T., Calhoun, J. H. (2004). Osteomyelitis in Long Bones. JBJS 86: 2305-2318 [Abstract] [Full Text]  
• Koort, J. K., Makinen, T. J., Knuuti, J., Jalava, J., Aro, H. T. (2004). Comparative 18F-FDG PET of Experimental Staphylococcus aureus Osteomyelitis and Normal Bone Healing. JNM 45: 1406-1411 [Abstract] [Full Text]  
• Asensi, V., Valle, E., Meana, A., Fierer, J., Celada, A., Alvarez, V., Paz, J., Coto, E., Carton, J. A., Maradona, J. A., Dieguez, A., Sarasua, J., Ocana, M. G., Arribas, J. M. (2004). In Vivo Interleukin-6 Protects Neutrophils from Apoptosis in Osteomyelitis. Infect. Immun. 72: 3823-3828 [Abstract] [Full Text]  
• Darley, E. S. R., MacGowan, A. P. (2004). Antibiotic treatment of Gram-positive bone and joint infections. J Antimicrob Chemother 53: 928-935 [Abstract] [Full Text]  
• Wright, K. M., Friedland, J. S. (2004). Regulation of monocyte chemokine and MMP-9 secretion by proinflammatory cytokines in tuberculous osteomyelitis. J. Leukoc. Biol. 75: 1086-1092 [Abstract] [Full Text]  
• Marriott, I., Gray, D. L., Tranguch, S. L., Fowler, V. G. Jr, Stryjewski, M., Scott Levin, L., Hudson, M. C., Bost, K. L. (2004). Osteoblasts Express the Inflammatory Cytokine Interleukin-6 in a Murine Model of Staphylococcus aureus Osteomyelitis and Infected Human Bone Tissue. Am. J. Pathol. 164: 1399-1406 [Abstract] [Full Text]  
• Smith, C. L. (2004). Pharmacotherapy of Diabetic Foot Ulcers. Journal of Pharmacy Practice 17: 66-74 [Abstract]  
• Tice, A. D., Hoaglund, P. A., Shoultz, D. A. (2003). Risk factors and treatment outcomes in osteomyelitis. J Antimicrob Chemother 51: 1261-1268 [Abstract] [Full Text]  
• Nathwani, D., Barlow, G. D., Ajdukiewicz, K., Gray, K., Morrison, J., Clift, B., France, A. J., Davey, P. (2003). Cost-minimization analysis and audit of antibiotic management of bone and joint infections with ambulatory teicoplanin, in-patient care or outpatient oral linezolid therapy. J Antimicrob Chemother 51: 391-396 [Abstract] [Full Text]  
• Schiesser, M., Stumpe, K. D. M., Trentz, O., Kossmann, T., von Schulthess, G. K. (2003). Detection of Metallic Implant-associated Infections with FDG PET in Patients with Trauma: Correlation with Microbiologic Results. Radiology 226: 391-398 [Abstract] [Full Text]  
• Gasper, N. A., Petty, C. C., Schrum, L. W., Marriott, I., Bost, K. L. (2002). Bacterium-Induced CXCL10 Secretion by Osteoblasts Can Be Mediated in Part through Toll-Like Receptor 4. Infect. Immun. 70: 4075-4082 [Abstract] [Full Text]  
• Senneville, E., Yazdanpanah, Y., Cazaubiel, M., Cordonnier, M., Valette, M., Beltrand, E., Khazarjian, A., Maulin, L., Alfandari, S., Caillaux, M., Dubreuil, L., Mouton, Y. (2001). Rifampicin-ofloxacin oral regimen for the treatment of mild to moderate diabetic foot osteomyelitis. J Antimicrob Chemother 48: 927-930 [Abstract] [Full Text]  
• Osmon, D. R. (2001). Antimicrobial Resistance: Guidelines for the Practicing Orthopaedic Surgeon. JBJS 83: 1891-1901 [Full Text]  
• Gratz, S., Rennen, H. J.J.M., Boerman, O. C., Oyen, W. J.G., Burma, P., Corstens, F. H.M. (2001). 99mTc-Interleukin-8 for Imaging Acute Osteomyelitis. JNM 42: 1257-1264 [Abstract] [Full Text]  
• Sinha, B., Francois, P., Que, Y.-A., Hussain, M., Heilmann, C., Moreillon, P., Lew, D., Krause, K.-H., Peters, G., Herrmann, M. (2000). Heterologously Expressed Staphylococcus aureus Fibronectin-Binding Proteins Are Sufficient for Invasion of Host Cells. Infect. Immun. 68: 6871-6878 [Abstract] [Full Text]  
• Bost, K. L., Bento, J. L., Ellington, J. K., Marriott, I., Hudson, M. C. (2000). Induction of Colony-Stimulating Factor Expression following Staphylococcus or Salmonella Interaction with Mouse or Human Osteoblasts. Infect. Immun. 68: 5075-5083 [Abstract] [Full Text]  
• Mayer, K. H., Rosenberg, A. E. (2000). Case 23-2000- A 49-Year-Old Man with the Acquired Immunodeficiency Syndrome and a Tibial Lesion. NEJM 343: 281-287 [Full Text]  
• Naktin, J., DeSimone, J. (1999). Lumbar Vertebral Osteomyelitis with Mycotic Abdominal Aortic Aneurysm Caused by Highly Penicillin-Resistant Streptococcus pneumoniae. J. Clin. Microbiol. 37: 4198-4200 [Abstract] [Full Text]  
• Bureau, N. J., Chhem, R. K., Cardinal, E. (1999). Musculoskeletal Infections: US Manifestations. RadioGraphics 19: 1585-1592 [Abstract] [Full Text]  
• Jain, A., Ben-Ami, T., Daum, R. S. (1999). Staphylococcal Infections in Children: Part 2. Pediatr. Rev. 20: 219-227 [Full Text]  
• Venkatachalam, S, Dennison, E., Sampson, M., Hockey, P., Cawley, M I D, Cooper, C. (1999). MASTERCLASS: An unusual cause of back pain in osteoporosis: lessons from a spinal lesion. Ann Rheum Dis 58: 327-331 [Full Text]  
• Stein, A., Bataille, J. F., Drancourt, M., Curvale, G., Argenson, J. N., Groulier, P., Raoult, D. (1998). Ambulatory Treatment of Multidrug-Resistant Staphylococcus-Infected Orthopedic Implants with High-Dose Oral Co-trimoxazole (Trimethoprim-Sulfamethoxazole). Antimicrob. Agents Chemother. 42: 3086-3091 [Abstract] [Full Text]  
• Aubry-Damon, H., Soussy, C.-J., Courvalin, P. (1998). Characterization of Mutations in the rpoB Gene That Confer Rifampin Resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 42: 2590-2594 [Abstract] [Full Text]  
• Zimmerli, W., Widmer, A. F., Blatter, M., Frei, R., Ochsner, P. E., for the Foreign-Body Infection Study Group, (1998). Role of Rifampin for Treatment of Orthopedic Implant-Related Staphylococcal Infections: A Randomized Controlled Trial. JAMA 279: 1537-1541 [Abstract] [Full Text]  
• Glatt, A. E., Shea, K. W., Lew, D. P., Waldvogel, F. (1997). Osteomyelitis. NEJM 337: 428-429 [Full Text]