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Previous Volume 336:1090-1091 April 10, 1997 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Severe, widespread psoriasis is a devastating skin disease that can disrupt professional, social, and private life. The effectiveness of photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA)¹ in inducing and maintaining the remission of severe psoriasis has been amply documented^1,2 and confirmed in large-scale cooperative clinical trials in both the United States³ and Europe.⁴ PUVA induces remission of psoriasis through repeated, controlled phototoxic reactions that occur only when psoralens are photoactivated by ultraviolet A. Neither the drug nor ultraviolet A is effective alone.⁵ Given the penetration characteristics of ultraviolet A, the absorption of photons is confined to the . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Margolis, D., Bilker, W., Hennessy, S., Vittorio, C., Santanna, J., Strom, B. L. (2001). The Risk of Malignancy Associated With Psoriasis. Arch Dermatol 137: 778-783 [Abstract] [Full Text]  
• Monti, P., Inga, A., Aprile, A., Campomenosi, P., Menichini, P., Ottaggio, L., Viaggi, S., Ghigliotti, G., Abbondandolo, A., Fronza, G. (2000). p53 mutations experimentally induced by 8-methoxypsoralen plus UVA (PUVA) differ from those found in human skin cancers in PUVA-treated patients. Mutagenesis 15: 127-132 [Abstract] [Full Text]  
• Boehncke, W.-H., Elshorst-Schmidt, T., Kaufmann, R. (2000). Systemic Photodynamic Therapy Is a Safe and Effective Treatment for Psoriasis. Arch Dermatol 136: 271-272 [Full Text]