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Previous Volume 336:1192 April 17, 1997 Number 16 Next

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Fourth edition. Edited by James F. Holland, Robert C. Bast, Jr., Donald L. Morton, Emil Frei III, Donald W. Kufe, and Ralph R. Weichselbaum. 3386 pp. in two volumes, illustrated. Baltimore, Williams & Wilkins, 1996. $229. ISBN 0-683-04095-2.
Edited by Joseph R. Bertino. 2134 pp. San Diego, Calif., Academic Press, 1996. $475. ISBN 0-12-093230-X.

Progress in molecular and cellular biology increasingly influences research on cancer medicine. Advances in recent years have produced powerful new methods of diagnosing and treating malignant diseases. New techniques, such as in situ hybridization and the polymerase chain reaction, are now routinely used in diagnosis. A plethora of new genes involved in the suppression or promotion of tumor-cell growth have been identified and cloned. Monoclonal antibodies have allowed more than 200 cluster determinants on nucleated blood cells to be identified, making a substantial contribution to the characterization of novel cytokines and their receptors. One consequence of all this is that . . . [Full Text of this Article]

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