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Previous Volume 336:1224-1234 April 24, 1997 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Sarcoidosis is a systemic disorder of unknown cause that is characterized by its pathological hallmark, the noncaseating granuloma. Its presenting features are protean, ranging from asymptomatic but abnormal findings on chest radiography in many patients to progressive multiorgan failure in an unfortunate minority. The illness can be self-limited or chronic, with episodic recrudescence and remissions. Because the lungs and thoracic lymph nodes are almost always involved, most patients report acute or insidious respiratory problems, variably accompanied by symptoms affecting the skin, eyes, or other organs. The diverse manifestations of this disorder help fuel the prevailing hypothesis that sarcoidosis has more . . . [Full Text of this Article]

Epidemiology and Pathogenesis

Pathogenesis

Genetic Factors

Pathological and Immunologic Features

Clinical Features

Diagnosis

Organ Involvement

Respiratory Tract

Lymphatic System

Heart

Skin

Eyes

Nervous System

Renal and Endocrine Systems

Liver

Natural History and Prognosis

Treatment

Special Treatment Issues

            Endobronchial Sarcoidosis

            End-Stage Pulmonary Disease

            Cardiac Sarcoidosis

            Dermatologic Sarcoidosis

            Ocular Sarcoidosis

            Neurologic Sarcoidosis

            Renal and Endocrine Sarcoidosis

Source Information

From the Department of Medicine, Pulmonary Division and Occupational–Environmental Medicine Section, National Jewish Medical and Research Center (L.S.N., C.S.R.); and the Department of Medicine, Division of Pulmonary Science and Critical Care Medicine (L.S.N., C.S.R., L.A.M.), and the Department of Preventive Medicine and Biometrics (L.S.N., C.S.R.), University of Colorado Health Sciences Center — both in Denver.

Address reprint requests to Dr. Newman at the National Jewish Medical and Research Center, 1400 Jackson St., Rm. G-010, Denver, CO 80206.

References

Related Letters:

Sarcoidosis
Schmit A., Van Gossum A., Piagnerelli M., Vanhaeverbeek M., Díaz F., Salvatori R., Palmer S. M., Miralles A. P., Tapson V. F., Than N., Turney J. H., Newman L. S., Rose C. S., Maier L. A.
Extract | Full Text  
N Engl J Med 1997; 337:789-791, Sep 11, 1997. Correspondence

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