FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 336:1328-1329 May 1, 1997 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

To the Editor: Artemisinin compounds are used to treat Plasmodium falciparum infections in many countries worldwide.^1,2 We describe a patient with acute cerebellar dysfunction that was temporally associated with the ingestion of artesunate.

In July 1996, a 36-year-old American geologist in Ghana had fever and chills without associated neurologic symptoms. His blood smear revealed P. falciparum. He proceeded to a local market and purchased a pack of artesunate tablets manufactured in China. He took two tablets on day 1, followed by one tablet daily for the next four days. He became afebrile on day 2. A blood smear on day . . . [Full Text of this Article]

References

Related Letters:

Artesunate and Cerebellar Dysfunction in Falciparum Malaria
Davis T. M.E., Edwards G. O., McCarthy J. S., Gachot B., Eliaszewicz M., Dupont B., Miller L. G., Panosian C. B.
Extract | Full Text  
N Engl J Med 1997; 337:792-793, Sep 11, 1997. Correspondence

This article has been cited by other articles:

• Cairo, J., Durand, S., Marquino, W., Cabezas, C., Lachira, A., Quintana, F., Vegas, W., Ruebush, T. K. II, Utz, G., Bacon, D. J. (2008). Surveillance for Adverse Drug Reactions to Combination Antimalarial Therapy with Sulfadoxine-Pyrimethamine plus Artesunate in Peru. Am J Trop Med Hyg 79: 42-44 [Abstract] [Full Text]  
• Rosenthal, P. J. (2008). Artesunate for the Treatment of Severe Falciparum Malaria. NEJM 358: 1829-1836 [Full Text]  
• Davis, T. M. E., Binh, T. Q., Ilett, K. F., Batty, K. T., Phuong, H. L., Chiswell, G. M., Phuong, V. D. B., Agus, C. (2003). Penetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intravenous Artesunate in Severe Falciparum Malaria. Antimicrob. Agents Chemother. 47: 368-370 [Abstract] [Full Text]  
• Davis, T. M. E., Phuong, H. L., Ilett, K. F., Hung, N. C., Batty, K. T., Phuong, V. D. B., Powell, S. M., Thien, H. V., Binh, T. Q. (2001). Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate in Severe Falciparum Malaria. Antimicrob. Agents Chemother. 45: 181-186 [Abstract] [Full Text]  
• Ittarat, W., Looareesuwan, S., Pootrakul, P., Sumpunsirikul, P., Vattanavibool, P., Meshnick, S. R. (1998). Effects of alpha -Thalassemia on Pharmacokinetics of the Antimalarial Agent Artesunate. Antimicrob. Agents Chemother. 42: 2332-2335 [Abstract] [Full Text]  
• Grace, J. M., Aguilar, A. J., Trotman, K. M., Brewer, T. G. (1998). Metabolism of beta -Arteether to Dihydroqinghaosu by Human Liver Microsomes and Recombinant Cytochrome P450. Drug Metab. Dispos. 26: 313-317 [Abstract] [Full Text]  
• Davis, T. M.E., Edwards, G. O., McCarthy, J. S., Gachot, B., Eliaszewicz, M., Dupont, B., Miller, L. G., Panosian, C. B. (1997). Artesunate and Cerebellar Dysfunction in Falciparum Malaria. NEJM 337: 792-793 [Full Text]