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Figure 1. This cell was found in the bone marrow aspirate of a 62-year-old woman with long-standing myelodysplasia, a disorder in which all cell lines of the bone marrow (myeloid, erythroid, and megakaryocytic) show dysplastic changes. This question-mark–shaped polymorphonuclear leukocyte shows characteristic hypolobation and budding of the nucleus and hypogranulation of its cytoplasm (Wright–Giemsa stain, x1000). The pseudo-Pelger–Huët anomaly, another acquired disorder in which neutrophils have a bilobed peanut- or eyeglasses-shaped nucleus, has a different appearance. The true Pelger–Huët anomaly is autosomal dominant and is not associated with myelodysplasia or any malignant condition, and affected cells are functionally . . . [Full Text of this Article] |
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