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Correspondence
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Volume 336:1388-1389 May 8, 1997 Number 19
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Endometrial Carcinoma

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 by Rose, P. G.
To the Editor: In his excellent review of endometrial carcinoma (Aug. 29 issue),1 Dr. Rose correctly describes the important etiologic role of unopposed estrogen, pointing out that "excessive estrogen is associated with most of the risk factors that have been linked to endometrial carcinoma." However, in the section on screening, Dr. Rose fails to discuss a plasma or saliva assay for estrogen and progesterone. It is the ratio of estrogen to progesterone that determines what level of estrogen is excessive. Prevention being better than early diagnosis of an existing carcinoma, one would think that testing for both hormones should be . . . [Full Text of this Article]

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