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Correspondence
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Volume 336:138 January 9, 1997 Number 2
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Ritonavir and Renal Failure

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To the Editor: Ritonavir (Norvir, Abbott Laboratories), a protease inhibitor used to treat people with human immunodeficiency virus (HIV) infection, reportedly has no adverse effects on renal function.1,2 We describe a patient in whom acute renal failure developed shortly after the start of treatment with ritonavir.

The patient was a 40-year-old man with HIV infection and stable chronic renal failure. His kidney disease was thought to be due to a horseshoe kidney and to glomerular disease of unknown cause, manifested by an episode of proteinuria in the nephrotic range and, more recently, by the excretion of 1 to 2 g . . . [Full Text of this Article]

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