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Previous Volume 336:1456-1457 May 15, 1997 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their study of immunohistochemical staining of the DCC protein and its association with the prognosis of colorectal cancer (Dec. 5 issue),¹ Shibata et al. report that the absence of stainable DCC is predictive of mortality. Absence of evidence, however, is not evidence of absence. The authors used tissues that were paraffin-embedded, a method of preparation that may extract stainable moieties from cells and thus result in false negative results. Inasmuch as the authors found it necessary to employ a harsh protocol, involving microwaving cells under pressure, to enhance the performance of their staining procedure, one wonders . . . [Full Text of this Article]

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