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Volume 336:1676-1677 June 5, 1997 Number 23
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Implantable Defibrillators in Patients with Coronary Artery Disease at High Risk for Ventricular Arrhythmia

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 by Singh, S. N.
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 by Moss, A. J.
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To the Editor: In their report on the Multicenter Automatic Defibrillator Implantation Trial (MADIT), Moss et al. (Dec. 26 issue)1 note the lower mortality in a group of patients receiving implantable defibrillators for unsustained ventricular tachycardia after myocardial infarction. However, the effect of the prophylactic use of defibrillators may have been confounded by other important differences between the two treatment groups. Beta-adrenergic antagonists are known to provide a benefit after myocardial infarction,2 and their more frequent use in the defibrillator group at the time of the last contact (27 percent, as compared with 5 percent in the conventional-therapy group) would . . . [Full Text of this Article]

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