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Correspondence
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Volume 336:1911-1913 June 26, 1997 Number 26
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Immunotherapy for Asthma

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 by Adkinson, N. F.
To the Editor: The failure of the study by Adkinson et al. (Jan. 30 issue)1 to demonstrate a significant benefit of immunotherapy with a few allergens to a particular group of children with asthma does not negate the positive benefit demonstrated in numerous other studies. The meta-analysis by Abramson et al.2 suggests that 33 negative studies would be necessary to overturn the results that demonstrated significant odds of symptomatic improvement, decreased medication use, reduction in bronchial hyperreactivity, and improvement in forced expiratory volume in one second with immunotherapy.

Some of the patients may have been sensitive to allergens not included . . . [Full Text of this Article]

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