Thymomas are rare epithelial neoplasms frequently associatedwith myasthenia gravis, hypogammaglobulinemia, and pure red-cellaplasia.1,2,3,4,5,6,7,8,9,10,11 In pure red-cell aplasia, autoantibodiesagainst early and late erythroid-cell progenitors or erythropoietin,as well as inhibitory cellular immune mechanisms, have beenimplicated.9,10,11 Limited information suggests that patientswith pure red-cell aplasia and thymoma have a poor prognosis.6,7,10
We recently demonstrated a high uptake of indium-labeled octreotide(111In-DTPA-d-Phe1-octreotide) in thymomas, a phenomenon relatedto the high content of somatostatin receptors in these tumors.12The same labeling method has been successful in imaging a widevariety of neuroendocrine tumors.13,14 Sixteen of 17 thymomaswe . . . [Full Text of this Article]
Case Report
Discussion
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From the Department of Molecular and Clinical Oncology and Endocrinology (G.P., A.C., E.B., G.L., A.R.B.) and the Department of Hematology (C.S., L.C.), School of Medicine, Federico II University; and the Department of Nuclear Medicine, National Cancer Institute G. Pascale (S.L., E.V., P.V., M.S.) both in Naples, Italy.
Address reprint requests to Dr. Palmieri at Via S. Pansini 5, 80131 Naples, Italy.
References
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