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Editorial
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Volume 336:433-434 February 6, 1997 Number 6
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Oral Anticoagulant Therapy for Venous Thromboembolism

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Patients with venous thromboembolic disease require treatment to stop the thrombotic process. The importance of immediate therapy with parenteral anticoagulants or thrombolytic agents (or both) is unquestioned.1,2 Furthermore, several well-designed clinical trials have demonstrated that oral anticoagulant therapy with warfarin derivatives prevents the development of recurrent thromboembolic disease,3,4,5,6 whereas inadequate anticoagulant therapy carries a risk of recurrent thromboembolism that can be as high as 25 percent.5 These studies also show that prolonged anticoagulant therapy is associated with an increased risk of bleeding.3,4,5,6 This risk can be lessened, but not eliminated, by appropriate monitoring of warfarin therapy.7,8 Moreover, with treatment, the . . . [Full Text of this Article]

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Related Letters:

Venous Thromboembolism
Block J. A., White T. M., Fetrow C.W., Schulman S., The Duration of Anticoagulation Trial Study Group , Diuguid D. L.
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N Engl J Med 1997; 337:51-53, Jul 3, 1997. Correspondence

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