Patients with venous thromboembolic disease require treatmentto stop the thrombotic process. The importance of immediatetherapy with parenteral anticoagulants or thrombolytic agents(or both) is unquestioned.1,2 Furthermore, several well-designedclinical trials have demonstrated that oral anticoagulant therapywith warfarin derivatives prevents the development of recurrentthromboembolic disease,3,4,5,6 whereas inadequate anticoagulanttherapy carries a risk of recurrent thromboembolism that canbe as high as 25 percent.5 These studies also show that prolongedanticoagulant therapy is associated with an increased risk ofbleeding.3,4,5,6 This risk can be lessened, but not eliminated,by appropriate monitoring of warfarin therapy.7,8 Moreover,with treatment, the . . . [Full Text of this Article]
References
Related Letters:
Venous Thromboembolism
Block J. A., White T. M., Fetrow C.W., Schulman S., The Duration of Anticoagulation Trial Study Group , Diuguid D. L.
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N Engl J Med 1997;
337:51-53, Jul 3, 1997.
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Block, J. A., White, T. M., Fetrow, C.W., Schulman, S., The Duration of Anticoagulation Trial Study Group, , Diuguid, D. L.
(1997). Venous Thromboembolism. NEJM
337: 51-53
[Full Text]