The role of digitalis in treating cardiovascular disease hasbeen at the center of the oldest continuing controversy in thehistory of medicine. Ever since its clinical introduction byWilliam Withering more than 200 years ago,1 physicians havedisagreed fiercely about the drug's efficacy and safety, withsome advocating its widespread use and others recommending thatits application be severely limited or abandoned entirely. Evidencefrom clinical studies published during the past decade has heightenedthe sophistication of the debate, but not diminished its intensity.
Advocates of digitalis have argued that the drug should be usedbecause it has been . . . [Full Text of this Article]
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Digoxin in Patients with Heart Failure
Umans V. A., Cornel J. H., Hic C., Soto J., Avendaño C., Vilchez F. G., Böhm M., Zoneraich S., Yusuf S., Gorlin R., Garg R., Packer M.
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N Engl J Med 1997;
337:129-131, Jul 10, 1997.
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