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In Patient 1, a 21-year-old woman with a six-month history of inhaling heroin vapor, progressive bradykinesia, ataxia, and slurred speech developed over a two-week period. She denied using intravenous drugs. On admission she had abulia. She followed simple, one-step commands, but there was a long period of latency before she initiated movements, which were slow and ataxic. She
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