Insulin-Like Growth Factors

doi:10.1056/NEJM199702273360907

Volume 336:633-640		February 27, 1997		Number 9

Insulin-Like Growth Factors

Derek Le Roith, M.D., Ph.D.

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The insulin-like growth factors (IGFs) participate in the growthand function of almost every organ in the body.¹ Because ofthe wide range of their biologic effects and their therapeuticpotential in a variety of clinical disorders, the IGFs havebecome the focus of research by an increasing number of investigators.²^,³^,⁴The object of this seminar is to review the clinical aspectsof the IGFs, including their potential therapeutic value, andto discuss briefly their structure, synthesis, regulation, andphysiologic role.

Basic Biochemistry and Physiologic Functions

Structure and Synthesis

The three peptide hormones, or growth factors, in the IGF family— insulin, IGF-I, and IGF-II — have approximately. . . [Full Text of this Article]

Physiologic Role and Mechanism of Action

Regulation and Differentiation of Function

Tissue IGFs

Pathologic Conditions Associated with Alterations in the IGF System

IGF-I

IGF-II

IGF-I as a Therapeutic Agent

Growth Hormone Insensitivity Syndrome

Insulin Resistance and Diabetes Mellitus

Severe Insulin Resistance

Insulin-Dependent Diabetes Mellitus

Non-Insulin-Dependent Diabetes Mellitus

Side Effects of Short-Term IGF-I Administration

Side Effects of Multiple Subcutaneous Doses of IGF-I

Conclusions

Discussion

Source Information

From the Diabetes Branch, National Institutes of Health, Rm. 85235A, Bldg. 10, Bethesda, MD 20892-1770, where reprint requests should be addressed to Dr. Le Roith.

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