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Previous Volume 336:650-651 February 27, 1997 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The muscular dystrophies are characterized by variable degrees of muscle weakness and degeneration. Their classification has traditionally been based on the phenotype and mode of inheritance. The molecular genetic revolution has now helped clarify but has also confounded our understanding of these disorders.

The well-known X-linked Duchenne's and Becker's types of muscular dystrophy are due to mutations in the same gene and result in abnormalities of dystrophin, its protein product. At a clinical level one can recognize a continuum from the severe Duchenne's type, with loss of ambulation before adolescence, through the mild Becker's form, in which ambulation is lost . . . [Full Text of this Article]

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