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Correspondence
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Volume 337:53-54 July 3, 1997 Number 1
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Massive Pulmonary Embolism

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 by van der Wouw, P. A.
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To the Editor: The Image in Clinical Medicine by van der Wouw and Bax (Feb. 6 issue)1 is a striking example of massive, fatal pulmonary embolism following deep venous thrombosis. Echocardiographic imaging nicely demonstrates the thrombus in transit in the right heart chambers and the pulmonary arteries. However, we disagree with the therapeutic strategy pursued by the treating physicians.

This elderly woman was recovering from a recent cerebral infarction when pulmonary embolism occurred. We believe that administering thrombolytic therapy with tissue plasminogen activator in this setting is dangerous, since it greatly increases the risk of cerebral hemorrhage. Stroke in the . . . [Full Text of this Article]

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