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Previous Volume 337:688-699 September 4, 1997 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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After almost two decades of intensive research, low-molecular-weight heparins have established their niche as an important class of antithrombotic compounds. The demonstration that these compounds are safe and effective for the prevention and treatment of venous thromboembolism has led to the licensing of several of them in Europe and North America. In addition, danaparoid sodium, which is a mixture of dermatan sulfate, heparan sulfate, and chondroitin sulfate, is often used for the treatment of heparin-induced thrombocytopenia.¹ Low-molecular-weight heparins have replaced unfractionated heparin in many parts of Europe but are only now finding their place in North America. Their use is . . . [Full Text of this Article]

Mechanisms of Action of Low-Molecular-Weight Heparins

Pharmacokinetics of Low-Molecular-Weight Heparins

Clinical Studies

Prophylaxis against Thromboembolism

General Surgery

Orthopedic Surgery of the Lower Limb

            Total Hip Replacement

            Total Knee Replacement

            Surgery for Hip Fracture

Acute Spinal Cord Injury

Multiple Trauma

Medical Conditions

Patency of Femoropopliteal Bypass Grafts

Restenosis after Angioplasty

Treatment of Thrombosis

Venous Thrombosis

Unstable Angina

Ischemic Stroke

Remaining Questions

Preoperative or Postoperative Dosing with Low-Molecular-Weight Heparins

Once-Daily versus Twice-Daily Dosing

Risk of Heparin-Induced Thrombocytopenia

Neutralization of Low-Molecular-Weight Heparins with Protamine Sulfate

Safety of Low-Molecular-Weight Heparins in Pregnancy

Risk of Heparin-Induced Osteoporosis

Comparability of Various Preparations of Low-Molecular-Weight Heparin

Cost Effectiveness

Summary

Source Information

From the Hamilton Civic Hospitals Research Centre and McMaster University, Hamilton, Ont., Canada.

Address reprint requests to Dr. Weitz at the Hamilton Civic Hospitals Research Centre, 711 Concession St., Hamilton, ON L8V 1C3, Canada.

References

Related Letters:

Low-Molecular-Weight Heparins
Horlocker T. T., Weitz J. I.
Extract | Full Text  
N Engl J Med 1998; 338:687-688, Mar 5, 1998. Correspondence

Enoxaparin in Neurosurgical Patients
Connolly E. S., Mocco J, Agnelli G., Iorio A.
Extract | Full Text  
N Engl J Med 1998; 339:1639-1640, Nov 26, 1998. Correspondence

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