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Correction to Bernard et al., N Engl J Med 336(13):912-918 March 27, 1997.

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Volume 337:710 September 4, 1997 Number 10
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Ibuprofen in Patients with Sepsis

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by Bernard, G. R.
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by Bernard, G. R.
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To the Editor: Bernard et al. (March 27 issue)1 report the results of a double-blind, randomized, placebo-controlled study of intravenous ibuprofen in patients with sepsis. They conclude that treatment with ibuprofen is safe in these patients and has a favorable effect on fever, tachycardia, oxygen consumption, and lactic acidosis, but not on mortality. We are concerned about this report and its conclusions.

There is abundant evidence that arachidonic acid metabolites act as endogenous regulators of cytokine production.2 Prostaglandin E2 inhibits the release of interleukin-1 and tumor necrosis factor {alpha} (TNF-{alpha}).3 We tested the effect of ibuprofen on serum levels of . . . [Full Text of this Article]

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