To the Editor: The review article by Forni and Hilton on continuoushemofiltration for the treatment of acute renal failure (May1 issue)1 suggests that this therapy should be used more widely.That may prove to be the case. However, as the article notes,there is little support for this approach in published reports.None of the references cited demonstrated in a randomized, controlledtrial that this therapy reduces morbidity or mortality. Moreover,a preliminary report of a multicenter randomized trial comparingcontinuous therapy with intermittent dialysis found that continuoustherapy had no benefit.2
Ramachandran, M., Ward, K., Brown, R. R., Munns, C. F., Cowell, C. T., Little, D. G.
(2007). Intravenous Bisphosphonate Therapy for Traumatic Osteonecrosis of the Femoral Head in Adolescents. JBJS
89: 1727-1734
[Abstract][Full Text]
Agarwala, S., Jain, D., Joshi, V. R., Sule, A.
(2005). Efficacy of alendronate, a bisphosphonate, in the treatment of AVN of the hip. A prospective open-label study. Rheumatology (Oxford)
44: 352-359
[Abstract][Full Text]