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Correspondence
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Volume 337:787-789 September 11, 1997 Number 11
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Risk of Breast Cancer in Carriers of BRCA Gene Mutations

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 by Healy, B.
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 by Schrag, D.
To the Editor: The report by Schrag and colleagues (May 15 issue)1 is of epidemiologic interest but of no great clinical use to women at risk for carrying BRCA1 or BRCA2 mutations or to the physicians caring for them. The results are presented to demonstrate the average effect of prophylactic surgery in a population of women at risk. For a woman at risk for breast or ovarian cancer, the development of the disease is an all-or-none phenomenon. The study is lacking in that the data are not presented in such a way that one can estimate the degree of risk . . . [Full Text of this Article]

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