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Previous Volume 337:792-793 September 11, 1997 Number 11 Next

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To the Editor: Miller and Panosian (May 1 issue)¹ report an association between artesunate and a post-treatment cerebellar syndrome in falciparum malaria. As they state, no overt neurotoxicity has been reported in over a million patients with malaria who were treated with artemisinin derivatives. We treated two patients who had undergone splenectomy with prolonged courses of artesunate, artemisinin, or both to achieve parasite clearance (total doses, 165 mg per kilogram of body weight and 46 mg per kilogram over periods of 12 and 11 days, respectively), without neurotoxicity in either.² Postmortem examination of the brain stem from another patient with . . . [Full Text of this Article]

References

Related Letters:

Ataxia and Slurred Speech after Artesunate Treatment for Falciparum Malaria
Miller L. G., Panosian C. B.
Extract | Full Text  
N Engl J Med 1997; 336:1328-1329, May 1, 1997. Correspondence

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