It has been almost three years since the Journal1 publishedthe results of AIDS Clinical Trials Group (ACTG) Study 076,the first randomized, controlled trial in which an interventionwas proved to reduce the incidence of human immunodeficiencyvirus (HIV) infection. The antiretroviral drug zidovudine, administeredorally to HIV-positive pregnant women in the United States andFrance, administered intravenously during labor, and subsequentlyadministered to the newborn infants, reduced the incidence ofHIV infection by two thirds.2 The regimen can save the lifeof one of every seven infants born to HIV-infected women.
Inadequate Analysis of Data from ACTG 076 and Other Sources
Defining Placebo as the Standard of Care in Developing Countries
Justifying Placebo-Controlled Trials by Claiming They Are More Rapid
Toward a Single International Standard of Ethical Research
References
Related Letters:
Ethics of Placebo-Controlled Trials of Zidovudine to Prevent the Perinatal Transmission of HIV in the Third World
Merson M. H., Simonds R.J., Rogers M. F., Dondero T. J., Francis D. P., Mbidde E. K., Blanche S., Kim R. J., Sharif S. K., Tafesse E., Murphy T. F., IJsselmuiden C. B., Herrington D., Piot P., Glantz L. H., Grodin M. A., Lallemant M., McIntosh K., Jourdain G., Le Coeur S., Vithayasai V., Lee T.-H., Hammer S., Prescott N., Essex M., Lurie P., Wolfe S. M.
Extract |
Full Text
N Engl J Med 1998;
338:836-841, Mar 19, 1998.
Correspondence
Informed Consent for a Clinical Trial in Thailand
Achrekar A., Gupta R., Pichayangkura C., Chokewiwat V., Limpakarnjanarat K., Chuachoowong R., Bhadrakom C., Siriwasin W., Chearskul S., Chotpitayasunondh T., Shaffer N.
Extract |
Full Text
N Engl J Med 1998;
339:1331-1332, Oct 29, 1998.
Correspondence
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