Amyloidosis is not a single disease but a term for diseasesthat share a common feature: the extracellular deposition ofpathologic insoluble fibrillar proteins in organs and tissues.In the mid-19th century, Virchow adopted the botanical term"amyloid," meaning starch or cellulose, to describe abnormalextracellular material seen in the liver at autopsy.1 Subsequently,amyloid was found to stain with Congo red, appearing red microscopicallyin normal light but apple green when viewed in polarized light.2,3Almost a century after Virchow's observations, the fibrillarnature of amyloid was described with the use of electron microscopyand the characteristic beta-pleated–sheet configuration,. . . [Full Text of this Article]
Classification and Epidemiology
Pathogenesis
AL Amyloidosis
Familial Amyloidoses
Secondary Amyloidosis
Clinical Features
AL Amyloidosis
ATTR Amyloidosis
AA Amyloidosis
Diagnosis
Imaging Techniques
Prognosis
Treatment
AL Amyloidosis
ATTR Amyloidosis
Conclusions
Source Information
From the Amyloid Treatment and Research Program (R.H.F., R.L.C., M.S.), Department of Medicine, and the Transfusion Medicine Program (R.L.C.), Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston University School of Medicine, Boston.
Address reprint requests to Dr. Falk at the Section of Cardiology, Boston Medical Center, D 8, E. Newton St. Campus, 1 Boston Medical Center Pl., Boston, MA 02118.
References
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The Systemic Amyloidoses
Dhodapkar M., Barlogie B., Gertz M., Jacobson D. R., Gallo G., Buxbaum J. N., Mahmoud S., Falk R. H., Comenzo R. L., Skinner M.
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N Engl J Med 1998;
338:264-265, Jan 22, 1998.
Correspondence
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