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Correspondence
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Volume 337:1009-1010 October 2, 1997 Number 14
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Possible Adverse Fetal Effect of Insulin Lispro

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 by Holleman, F.
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To the Editor: Insulin lispro is a new insulin analogue that acts more rapidly than regular insulin. To date, there are no reports on fetal outcomes after therapy with insulin lispro in pregnant women; indeed, pregnancy has been a contraindication for its use in all of the drug studies.1

We report on two primiparous women treated with NPH insulin and insulin lispro during pregnancy. Both had well-controlled insulin-dependent diabetes mellitus with no evidence of complications at the time of conception. Excellent glycemic control was maintained throughout their pregnancies, with hemoglobin A 1c values (measured every three months) of less than 7.0 . . . [Full Text of this Article]

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