Postoperative Radiotherapy in High-Risk Premenopausal Women with Breast Cancer Who Receive Adjuvant Chemotherapy
Marie Overgaard, M.D., Per S. Hansen, M.D., Jens Overgaard, M.D., Carsten Rose, M.D., Michael Andersson, M.D., Flemming Bach, M.D., Mogens Kjaer, M.D., Carl C. Gadeberg, M.D., Henning T. Mouridsen, M.D., Maj-Britt Jensen, M.Sc., Karin Zedeler, M.Sc., for The Danish Breast Cancer Cooperative Group 82b Trial
Background Irradiation after mastectomy can reduce locoregionalrecurrences in women with breast cancer, but whether it prolongssurvival remains controversial. We conducted a randomized trialof radiotherapy after mastectomy in high-risk premenopausalwomen, all of whom also received adjuvant systemic chemotherapywith cyclophosphamide, methotrexate, and fluorouracil (CMF).
Methods A total of 1708 women who had undergone mastectomy forpathological stage II or III breast cancer were randomly assignedto receive eight cycles of CMF plus irradiation of the chestwall and regional lymph nodes (852 women) or nine cycles ofCMF alone (856 women). The median length of follow-up was 114months. The end points were locoregional recurrence, distantmetastases, disease-free survival, and overall survival.
Results The frequency of locoregional recurrence alone or withdistant metastases was 9 percent among the women who receivedradiotherapy plus CMF and 32 percent among those who receivedCMF alone (P<0.001). The probability of survival free ofdisease after 10 years was 48 percent among the women assignedto radiotherapy plus CMF and 34 percent among those treatedonly with CMF (P<0.001). Overall survival at 10 years was54 percent among those given radiotherapy and CMF and 45 percentamong those who received CMF alone (P<0.001). Multivariateanalysis demonstrated that irradiation after mastectomy significantlyimproved disease-free survival and overall survival, irrespectiveof tumor size, the number of positive nodes, or the histopathologicalgrade.
Conclusions The addition of postoperative irradiation to mastectomyand adjuvant chemotherapy reduces locoregional recurrences andprolongs survival in high-risk premenopausal women with breastcancer.
Source Information
From the Department of Oncology, Aarhus University Hospital, Aarhus (M.O.); the Department of Medicine, Viborg County Hospital, Viborg (P.S.H.); the Danish Cancer Society and the Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus (J.O.); the Department of Oncology, Odense University Hospital, Odense (C.R.); the Department of Oncology, Rigshospitalet, Copenhagen (M.A., H.T.M.); the Department of Oncology, Copenhagen University Hospital, Herlev (F.B.); the Department of Oncology, Aalborg County Hospital, Aalborg (M.K.); the Department of Oncology, Vejle County Hospital, Vejle (C.C.G.); and the Danish Breast Cancer Cooperative Group Secretariat, Rigshospitalet, Copenhagen (H.T.M., M.-B.J., K.Z.) — all in Denmark.
Address reprint requests to Dr. Overgaard at the Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, Bldg. 5, DK-8000 Aarhus C, Denmark.
Radiotherapy and Chemotherapy in High-Risk Breast Cancer
El-Tamer M., Homel P., Braverman A. S., Wolberg W. H., Robins H. I., Goldhirsch A., Coates A. S., Colleoni M., Gelber R. D., Raffle A.E., Evans R. A., Overgaard M., Rose C., Mouridsen H., Ragaz J., Jackson S. M., Spinelli J. J., Hellman S.
Extract |
Full Text
N Engl J Med 1998;
338:329-333, Jan 29, 1998.
Correspondence
This article has been cited by other articles:
Chen, R. C., Lin, N. U., Golshan, M., Harris, J. R., Bellon, J. R.
(2008). Internal Mammary Nodes in Breast Cancer: Diagnosis and Implications for Patient Management--A Systematic Review. JCO
26: 4981-4989
[Abstract][Full Text]
Veronesi, U., Arnone, P., Veronesi, P., Galimberti, V., Luini, A., Rotmensz, N., Botteri, E., Ivaldi, G. B., Leonardi, M. C., Viale, G., Sagona, A., Paganelli, G., Panzeri, R., Orecchia, R.
(2008). The value of radiotherapy on metastatic internal mammary nodes in breast cancer. Results on a large series. Ann Oncol
19: 1553-1560
[Abstract][Full Text]
Gruber, G., Cole, B. F., Castiglione-Gertsch, M., Holmberg, S. B., Lindtner, J., Golouh, R., Collins, J., Crivellari, D., Thurlimann, B., Simoncini, E., Fey, M. F., Gelber, R. D., Coates, A. S., Price, K. N., Goldhirsch, A., Viale, G., Gusterson, B. A., for the International Breast Cancer Study Group,
(2008). Extracapsular tumor spread and the risk of local, axillary and supraclavicular recurrence in node-positive, premenopausal patients with breast cancer. Ann Oncol
19: 1393-1401
[Abstract][Full Text]
Trock, B. J., Han, M., Freedland, S. J., Humphreys, E. B., DeWeese, T. L., Partin, A. W., Walsh, P. C.
(2008). Prostate Cancer-Specific Survival Following Salvage Radiotherapy vs Observation in Men With Biochemical Recurrence After Radical Prostatectomy. JAMA
299: 2760-2769
[Abstract][Full Text]
MUNSHI, A, MALLICK, I, BUDRUKKAR, A, JALALI, R, BADWE, R, DINSHAW, K A, SARIN, R
(2008). A novel method for CT-scan-based localization of the internal mammary chain by internal mammary catheterization: an aid in breast cancer radiation therapy planning. Br. J. Radiol.
81: 485-489
[Abstract][Full Text]
Glatstein, E., Glick, J., Kaiser, L., Hahn, S. M.
(2008). Should Randomized Clinical Trials Be Required for Proton Radiotherapy? An Alternative View. JCO
26: 2438-2439
[Full Text]
Marks, L. B., Zeng, J., Prosnitz, L. R.
(2008). One to Three Versus Four or More Positive Nodes and Postmastectomy Radiotherapy: Time to End the Debate. JCO
26: 2075-2077
[Full Text]
Thomson, H. J., Potter, S., Greenwood, R. J., Bahl, A., Barker, J., Cawthorn, S. J., Winters, Z. E.
(2008). A Prospective Longitudinal Study of Cosmetic Outcome in Immediate Latissimus Dorsi Breast Reconstruction and the Influence of Radiotherapy. Ann. Surg. Oncol.
15: 1081-1091
[Abstract][Full Text]
Kyndi, M., Sorensen, F. B., Knudsen, H., Overgaard, M., Nielsen, H. M., Overgaard, J.
(2008). Estrogen Receptor, Progesterone Receptor, HER-2, and Response to Postmastectomy Radiotherapy in High-Risk Breast Cancer: The Danish Breast Cancer Cooperative Group. JCO
26: 1419-1426
[Abstract][Full Text]
Kaufman, E. L., Jacobson, J. S., Hershman, D. L., Desai, M., Neugut, A. I.
(2008). Effect of Breast Cancer Radiotherapy and Cigarette Smoking on Risk of Second Primary Lung Cancer. JCO
26: 392-398
[Abstract][Full Text]
Morrogh, M., Borgen, P. I., King, T. A.
(2007). The Importance of Local Control in Early-Stage Breast Cancer: A Historical Review and a Discussion of Ongoing Issues. Ann. Surg. Oncol.
14: 3310-3320
[Full Text]
Yao, M. S., Kurland, B. F., Smith, A. H., Schubert, E. K., Dunnwald, L. K., Byrd, D. R., Mankoff, D. A.
(2007). Internal Mammary Nodal Chain Drainage Is a Prognostic Indicator in Axillary Node-Positive Breast Cancer. Ann. Surg. Oncol.
14: 2985-2993
[Abstract][Full Text]
Punglia, R. S., Morrow, M., Winer, E. P., Harris, J. R.
(2007). Local Therapy and Survival in Breast Cancer. NEJM
356: 2399-2405
[Full Text]
Karlsson, P., Cole, B. F., Price, K. N., Coates, A. S., Castiglione-Gertsch, M., Gusterson, B. A., Murray, E., Lindtner, J., Collins, J. P., Holmberg, S. B., Fey, M. F., Thurlimann, B., Crivellari, D., Forbes, J. F., Gelber, R. D., Goldhirsch, A., Wallgren, A.
(2007). The Role of the Number of Uninvolved Lymph Nodes in Predicting Locoregional Recurrence in Breast Cancer. JCO
25: 2019-2026
[Abstract][Full Text]
Le Pechoux, C., Dunant, A., Pignon, J.-P., De Ruysscher, D., Mornex, F., Senan, S., Casas, F., Price, A., Milleron, B.
(2007). Need for a New Trial to Evaluate Adjuvant Postoperative Radiotherapy in Non-Small-Cell Lung Cancer Patients With N2 Mediastinal Involvement. JCO
25: e10-e11
[Full Text]
Chagpar, A. B., Scoggins, C. R., Martin, R. C. G. 2nd, Cook, E. F., McCurry, T., Mizuguchi, N., Paris, K. J., Carlson, D. J., Laidley, A. L., El-Eid, S. E., McGlothin, T. Q., McMasters, K. M., for the University of Louisville Breast Sentinel L,
(2007). Predicting Patients at Low Probability of Requiring Postmastectomy Radiation Therapy. Ann. Surg. Oncol.
14: 670-677
[Abstract][Full Text]
Smith, B. D., Haffty, B. G., Hurria, A., Galusha, D. H., Gross, C. P.
(2006). Postmastectomy Radiation and Survival in Older Women With Breast Cancer. JCO
24: 4901-4907
[Abstract][Full Text]
Cheng, S. H., Horng, C.-F., West, M., Huang, E., Pittman, J., Tsou, M.-H., Dressman, H., Chen, C.-M., Tsai, S. Y., Jian, J. J., Liu, M.-C., Nevins, J. R., Huang, A. T.
(2006). Genomic Prediction of Locoregional Recurrence After Mastectomy in Breast Cancer. JCO
24: 4594-4602
[Abstract][Full Text]
Taghian, A. G., Jeong, J.-H., Mamounas, E. P., Parda, D. S., Deutsch, M., Costantino, J. P., Wolmark, N.
(2006). Low Locoregional Recurrence Rate Among Node-Negative Breast Cancer Patients With Tumors 5 cm or Larger Treated by Mastectomy, With or Without Adjuvant Systemic Therapy and Without Radiotherapy: Results From Five National Surgical Adjuvant Breast and Bowel Project Randomized Clinical Trials. JCO
24: 3927-3932
[Abstract][Full Text]
Shikama, N., Mitsumori, M., Yamauchi, C., Takekawa, H., Arakawa, K., Sasaki, S., Teshima, T.
(2006). Patterns of Care Study for Postmastectomy Radiotherapy in Japan: Its Role in Monitoring the Patterns of Changes in Practice. Jpn J Clin Oncol
36: 499-503
[Abstract][Full Text]
Punglia, R. S., Weeks, J. C., Neville, B. A., Earle, C. C.
(2006). Radiation Therapy After Mastectomy Between 1991 and 1999 in Elderly Women: Response to Clinical Trial Information. JCO
24: 3474-3482
[Abstract][Full Text]
Kunkler, I., Russell, N., Canney, P., Venables, K., Bartlett, J.
(2006). Re: Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: a clinical perspective.. JNCI J Natl Cancer Inst
98: 1020-1021
[Full Text]
Atkins, C. D.
(2006). Re: Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: a clinical perspective.. JNCI J Natl Cancer Inst
98: 1021-1021
[Full Text]
Woodward, W. A., Vinh-Hung, V., Ueno, N. T., Cheng, Y. C., Royce, M., Tai, P., Vlastos, G., Wallace, A. M., Hortobagyi, G. N., Nieto, Y.
(2006). Prognostic Value of Nodal Ratios in Node-Positive Breast Cancer. JCO
24: 2910-2916
[Abstract][Full Text]
Morrow, M., Goldstein, L.
(2006). Surgery of the Primary Tumor in Metastatic Breast Cancer: Closing the Barn Door After the Horse Has Bolted?. JCO
24: 2694-2696
[Full Text]
Nielsen, H. M., Overgaard, M., Grau, C., Jensen, A. R., Overgaard, J.
(2006). Study of Failure Pattern Among High-Risk Breast Cancer Patients With or Without Postmastectomy Radiotherapy in Addition to Adjuvant Systemic Therapy: Long-Term Results From the Danish Breast Cancer Cooperative Group DBCG 82 b and c Randomized Studies. JCO
24: 2268-2275
[Abstract][Full Text]
Bear, H. D., Anderson, S., Smith, R. E., Geyer, C. E. Jr, Mamounas, E. P., Fisher, B., Brown, A. M., Robidoux, A., Margolese, R., Kahlenberg, M. S., Paik, S., Soran, A., Wickerham, D. L., Wolmark, N.
(2006). Sequential Preoperative or Postoperative Docetaxel Added to Preoperative Doxorubicin Plus Cyclophosphamide for Operable Breast Cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-27. JCO
24: 2019-2027
[Abstract][Full Text]
Haffty, B G, Silber, A, Matloff, E, Chung, J, Lannin, D
(2006). Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women. J. Med. Genet.
43: 133-137
[Abstract][Full Text]
International Breast Cancer Study Group,
(2006). Multicycle Dose-Intensive Chemotherapy for Women With High-Risk Primary Breast Cancer: Results of International Breast Cancer Study Group Trial 15-95. JCO
24: 370-378
[Abstract][Full Text]
Gebski, V., Lagleva, M., Keech, A., Simes, J., Langlands, A. O.
(2006). Survival Effects of Postmastectomy Adjuvant Radiation Therapy Using Biologically Equivalent Doses: A Clinical Perspective. JNCI J Natl Cancer Inst
98: 26-38
[Abstract][Full Text]
Davidson, N. E., Morrow, M., Kopans, D. B., Koerner, F. C.
(2005). Case 35-2005 -- A 56-Year-Old Woman with Breast Cancer and Isolated Tumor Cells in a Sentinel Lymph Node. NEJM
353: 2177-2185
[Full Text]
Prochazka, M., Hall, P., Gagliardi, G., Granath, F., Nilsson, B. N., Shields, P. G., Tennis, M., Czene, K.
(2005). Ionizing Radiation and Tobacco Use Increases the Risk of a Subsequent Lung Carcinoma in Women With Breast Cancer: Case-Only Design. JCO
23: 7467-7474
[Abstract][Full Text]
Patt, D. A., Goodwin, J. S., Kuo, Y.-F., Freeman, J. L., Zhang, D. D., Buchholz, T. A., Hortobagyi, G. N., Giordano, S. H.
(2005). Cardiac Morbidity of Adjuvant Radiotherapy for Breast Cancer. JCO
23: 7475-7482
[Abstract][Full Text]
Gruber, G., Bonetti, M., Nasi, M. L., Price, K. N., Castiglione-Gertsch, M., Rudenstam, C.-M., Holmberg, S. B., Lindtner, J., Golouh, R., Collins, J., Crivellari, D., Carbone, A., Thurlimann, B., Simoncini, E., Fey, M. F., Gelber, R. D., Coates, A. S., Goldhirsch, A.
(2005). Prognostic Value of Extracapsular Tumor Spread for Locoregional Control in Premenopausal Patients With Node-Positive Breast Cancer Treated With Classical Cyclophosphamide, Methotrexate, and Fluorouracil: Long-Term Observations From International Breast Cancer Study Group Trial VI. JCO
23: 7089-7097
[Abstract][Full Text]
Kunkler, I.
(2005). Re: Locoregional Radiation Therapy in Patients With High-Risk Breast Cancer Receiving Adjuvant Chemotherapy: 20-Year Results of the British Columbia Randomized Trial. JNCI J Natl Cancer Inst
97: 1162-1163
[Full Text]
Ragaz, J., Olivotto, I. A., Wilson, K. S., Spinelli, J. J., Durand, R.
(2005). RESPONSE: Re: Locoregional Radiation Therapy in Patients With High-Risk Breast Cancer Receiving Adjuvant Chemotherapy: 20-Year Results of the British Columbia Randomized Trial. JNCI J Natl Cancer Inst
97: 1163-1164
[Full Text]
Truong, P T, Berthelet, E, Patenaude, V, Bishop, J, Sandwith, B, Moravan, V, Beckham, W, Mitchell, T, Olivotto, I A
(2005). Setup variations in locoregional radiotherapy for breast cancer: an electronic portal imaging study. Br. J. Radiol.
78: 742-745
[Abstract][Full Text]
Kim, J. H., Bossuyt, V., Ponn, T., Lannin, D., Haffty, B. G.
(2005). Cyclooxygenase-2 Expression in Postmastectomy Chest Wall Relapse. Clin. Cancer Res.
11: 5199-5205
[Abstract][Full Text]
Bogart, J. A., Aronowitz, J. N.
(2005). Localized Non-Small Cell Lung Cancer: Adjuvant Radiotherapy in the Era of Effective Systemic Therapy. Clin. Cancer Res.
11: 5004s-5010s
[Abstract][Full Text]
Peters, W. P., Rosner, G. L., Vredenburgh, J. J., Shpall, E. J., Crump, M., Richardson, P. G., Schuster, M. W., Marks, L. B., Cirrincione, C., Norton, L., Henderson, I.C., Schilsky, R. L., Hurd, D. D.
(2005). Prospective, Randomized Comparison of High-Dose Chemotherapy With Stem-Cell Support Versus Intermediate-Dose Chemotherapy After Surgery and Adjuvant Chemotherapy in Women With High-Risk Primary Breast Cancer: A Report of CALGB 9082, SWOG 9114, and NCIC MA-13. JCO
23: 2191-2200
[Abstract][Full Text]
Cuzick, J.
(2005). Radiotherapy for Breast Cancer. JNCI J Natl Cancer Inst
97: 406-407
[Full Text]
Giordano, S. H., Kuo, Y.-F., Freeman, J. L., Buchholz, T. A., Hortobagyi, G. N., Goodwin, J. S.
(2005). Risk of Cardiac Death After Adjuvant Radiotherapy for Breast Cancer. JNCI J Natl Cancer Inst
97: 419-424
[Abstract][Full Text]
Harris, J. R.
(2005). Radiation Therapy for Invasive Breast Cancer: Not Just for Local Control. JCO
23: 1607-1608
[Full Text]
Pierce, L. J.
(2005). The Use of Radiotherapy After Mastectomy: A Review of the Literature. JCO
23: 1706-1717
[Full Text]
Whelan, T. J.
(2005). Use of Conventional Radiation Therapy As Part of Breast-Conserving Treatment. JCO
23: 1718-1725
[Full Text]
Colleoni, M., Zahrieh, D., Gelber, R. D., Holmberg, S. B., Mattsson, J. E., Rudenstam, C.-M., Lindtner, J., Erzen, D., Snyder, R., Collins, J., Fey, M. F., Thurlimann, B., Crivellari, D., Murray, E., Mendiola, C., Pagani, O., Castiglione-Gertsch, M., Coates, A. S., Price, K., Goldhirsch, A.
(2005). Site of Primary Tumor Has a Prognostic Role in Operable Breast Cancer: The International Breast Cancer Study Group Experience. JCO
23: 1390-1400
[Abstract][Full Text]
Smith, B. D., Smith, G. L., Haffty, B. G.
(2005). Postmastectomy Radiation and Mortality in Women With T1-2 Node-Positive Breast Cancer. JCO
23: 1409-1419
[Abstract][Full Text]
Zablotska, L. B., Chak, A., Das, A., Neugut, A. I.
(2005). Increased Risk of Squamous Cell Esophageal Cancer after Adjuvant Radiation Therapy for Primary Breast Cancer. Am J Epidemiol
161: 330-337
[Abstract][Full Text]
Ragaz, J., Olivotto, I. A., Spinelli, J. J., Phillips, N., Jackson, S. M., Wilson, Kenneth. S., Knowling, M. A., Coppin, C. M. L., Weir, L., Gelmon, K., Le, N., Durand, R., Coldman, A. J., Manji, M.
(2005). Locoregional Radiation Therapy in Patients With High-Risk Breast Cancer Receiving Adjuvant Chemotherapy: 20-Year Results of the British Columbia Randomized Trial. JNCI J Natl Cancer Inst
97: 116-126
[Abstract][Full Text]
Truong, P. T., Olivotto, I. A., Whelan, T. J., Levine, M.
(2005). Outcomes of postmastectomy radiotherapy. CMAJ
172: 19-19
[Full Text]
Sartor, C. I., Peterson, B. L., Woolf, S., FitzGerald, T. J., Laurie, F., Turrisi, A. J., Bogart, J., Henderson, I. C., Norton, L.
(2005). Effect of Addition of Adjuvant Paclitaxel on Radiotherapy Delivery and Locoregional Control of Node-Positive Breast Cancer: Cancer and Leukemia Group B 9344. JCO
23: 30-40
[Abstract][Full Text]
Huang, E. H., Tucker, S. L., Strom, E. A., McNeese, M. D., Kuerer, H. M., Buzdar, A. U., Valero, V., Perkins, G. H., Schechter, N. R., Hunt, K. K., Sahin, A. A., Hortobagyi, G. N., Buchholz, T. A.
(2004). Postmastectomy Radiation Improves Local-Regional Control and Survival for Selected Patients With Locally Advanced Breast Cancer Treated With Neoadjuvant Chemotherapy and Mastectomy. JCO
22: 4691-4699
[Abstract][Full Text]
Yu, T.-K., Whitman, G. J., Thames, H. D., Buzdar, A. U., Strom, E. A., Perkins, G. H., Schechter, N. R., McNeese, M. D., Kau, S.-W., Thomas, E. S., Hortobagyi, G. N., Buchholz, T. A.
(2004). Clinically Relevant Pneumonitis After Sequential Paclitaxel-Based Chemotherapy and Radiotherapy in Breast Cancer Patients. JNCI J Natl Cancer Inst
96: 1676-1681
[Abstract][Full Text]
Taghian, A., Jeong, J.-H., Mamounas, E., Anderson, S., Bryant, J., Deutsch, M., Wolmark, N.
(2004). Patterns of Locoregional Failure in Patients With Operable Breast Cancer Treated by Mastectomy and Adjuvant Chemotherapy With or Without Tamoxifen and Without Radiotherapy: Results From Five National Surgical Adjuvant Breast and Bowel Project Randomized Clinical Trials. JCO
22: 4247-4254
[Abstract][Full Text]
Olivotto, I. A., Truong, P. T., Chua, B.
(2004). Postmastectomy Radiation Therapy: Who Needs It?. JCO
22: 4237-4239
[Full Text]
Violet, J A, Harmer, C
(2004). Breast cancer: improving outcome following adjuvant radiotherapy. Br. J. Radiol.
77: 811-820
[Abstract][Full Text]
Hinrichs, C. S., Watroba, N. L., Rezaishiraz, H., Giese, W., Hurd, T., Fassl, K. A., Edge, S. B.
(2004). Lymphedema Secondary to Postmastectomy Radiation: Incidence and Risk Factors. Ann. Surg. Oncol.
11: 573-580
[Abstract][Full Text]
Nieto, Y., Nawaz, S., Shpall, E. J., Bearman, S. I., Murphy, J., Jones, R. B.
(2004). Long-Term Analysis and Prospective Validation of a Prognostic Model for Patients with High-Risk Primary Breast Cancer Receiving High-Dose Chemotherapy. Clin. Cancer Res.
10: 2609-2617
[Abstract][Full Text]
Truong, P. T., Olivotto, I. A., Whelan, T. J., Levine, M.
(2004). Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy. CMAJ
170: 1263-1273
[Abstract][Full Text]
Shenkier, T., Weir, L., Levine, M., Olivotto, I., Whelan, T., Reyno, L.
(2004). Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer. CMAJ
170: 983-994
[Abstract][Full Text]
Doekhie, F. S., Peeters, K. C. M. J., Tollenaar, R. A. E. M., van de Velde, C. J. H.
(2004). Minimal Residual Disease Assessment in Sentinel Nodes of Breast and Gastrointestinal Cancer: A Plea for Standardization. Ann. Surg. Oncol.
11: 236S-241S
[Abstract][Full Text]
Vallis, K. A., Tannock, I. F.
(2004). Postoperative Radiotherapy for Breast Cancer: Growing Evidence for an Impact on Survival. JNCI J Natl Cancer Inst
96: 88-89
[Full Text]
Manders, P., Sweep, F. C. G. J., Tjan-Heijnen, V. C. G., Geurts-Moespot, A., van Tienoven, D. T. H., Foekens, J. A., Span, P. N., Bussink, J., Beex, L. V. A. M.
(2003). Vascular Endothelial Growth Factor Independently Predicts the Efficacy of Postoperative Radiotherapy in Node-Negative Breast Cancer Patients. Clin. Cancer Res.
9: 6363-6370
[Abstract][Full Text]
Dodwell, D, Horgan, K
(2003). Locoregional treatment for breast cancer. BMJ
327: 1062-1063
[Full Text]
Cakir, S., Gursel, B., Meydan, D., Yildiz, L.
(2003). The Sequencing of Radiation Therapy and Chemotherapy after Mastectomy in Premenopausal Women with Breast Cancer. Jpn J Clin Oncol
33: 563-569
[Abstract][Full Text]
Arriagada, R., Le, M. G., Guinebretiere, J.-M., Dunant, A., Rochard, F., Tursz, T.
(2003). Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients. Ann Oncol
14: 1617-1622
[Abstract][Full Text]
Shikama, N., Nishikawa, A., Mitsumori, M., Hiraoka, M., Yamamoto, T., Teshima, T., Inoue, T., Wilson, F., Owen, J.
(2003). Patterns of Care Study: Comparison of Process of Post-mastectomy Radiotherapy (PMRT) in Japan and the USA. Jpn J Clin Oncol
33: 518-521
[Abstract][Full Text]
Mamounas, E. P.
(2003). NSABP Breast Cancer Clinical Trials: Recent Results and Future Directions. Clin Med Res
1: 309-326
[Abstract][Full Text]
Zippel, D., Papa, M.
(2003). Patients With Breast Cancer and Positive Sentinel Nodes: Axillary Dissection or Axillary Radiotherapy?. Arch Surg
138: 1159-1159
[Full Text]
Shikama, N., Sasaki, S., Mitsumori, M., Hiraoka, M., Yamauchi, C., Yamamoto, T., Teshima, T., Inoue, T.
(2003). Patterns of Care Study in Japan: Analysis of Patients Subjected to Mastectomy Followed by Radiotherapy. Jpn J Clin Oncol
33: 456-462
[Abstract][Full Text]
Stemmer, S. M., Rizel, S., Hardan, I., Adamo, A., Neumann, A., Goffman, J., Brenner, H. J., Pfeffer, M. R.
(2003). The Role of Irradiation of the Internal Mammary Lymph Nodes in High-Risk Stage II to IIIA Breast Cancer Patients After High-Dose Chemotherapy: A Prospective Sequential Nonrandomized Study. JCO
21: 2713-2718
[Abstract][Full Text]
Copeland, E. M. III
(2003). Breast Cancer: Specialists Do Make a Difference. Ann. Surg. Oncol.
10: 589-590
[Full Text]
Roach, M. III, DeSilvio, M., Lawton, C., Uhl, V., Machtay, M., Seider, M.J., Rotman, M., Jones, C., Asbell, S.O., Valicenti, R.K., Han, S., Thomas, C.R. Jr, Shipley, W.S.
(2003). Phase III Trial Comparing Whole-Pelvic Versus Prostate-Only Radiotherapy and Neoadjuvant Versus Adjuvant Combined Androgen Suppression: Radiation Therapy Oncology Group 9413. JCO
21: 1904-1911
[Abstract][Full Text]
Kunkler, I. H, Harnett, A. N
(2003). Cardiovascular mortality after radiotherapy for breast cancer. BMJ
326: 983-983
[Full Text]
Smith, R. E., Bryant, J., DeCillis, A., Anderson, S.
(2003). Acute Myeloid Leukemia and Myelodysplastic Syndrome After Doxorubicin-Cyclophosphamide Adjuvant Therapy for Operable Breast Cancer: The National Surgical Adjuvant Breast and Bowel Project Experience. JCO
21: 1195-1204
[Abstract][Full Text]
Wallgren, A., Bonetti, M., Gelber, R.D., Goldhirsch, A., Castiglione-Gertsch, M., Holmberg, S.B., Lindtner, J., Thurlimann, B., Fey, M., Werner, I.D., Forbes, J.F., Price, K., Coates, A.S., Collins, J.
(2003). Risk Factors for Locoregional Recurrence Among Breast Cancer Patients: Results From International Breast Cancer Study Group Trials I Through VII. JCO
21: 1205-1213
[Abstract][Full Text]
Foster, R. S. Jr
(2003). Breast Cancer Detection and Treatment: A Personal and Historical Perspective. Arch Surg
138: 397-408
[Full Text]
Sigurdson, E. R.
(2003). Lymph Node Dissection: Is It Diagnostic or Therapeutic?. JCO
21: 965-967
[Full Text]
Sharkis, D. H., Recht, A., Sonpavde, G., Veronesi, U., Mariani, L., Fisher, B., Anderson, S., Bryant, J.
(2003). Breast-Conserving Surgery for Breast Cancer. NEJM
348: 657-660
[Full Text]
Gaffney, D. K., Tsodikov, A., Wiggins, C. L.
(2003). Diminished Survival in Patients With Inner Versus Outer Quadrant Breast Cancers. JCO
21: 467-472
[Abstract][Full Text]
Guenther, J. M., Hansen, N. M., DiFronzo, L. A., Giuliano, A. E., Collins, J. C., Grube, B. L., O'Connell, T. X.
(2003). Axillary Dissection Is Not Required for All Patients With Breast Cancer and Positive Sentinel Nodes. Arch Surg
138: 52-56
[Abstract][Full Text]
Buchholz, T. A., Strom, E. A., Perkins, G. H., McNeese, M. D.
(2002). Controversies Regarding the Use of Radiation After Mastectomy in Breast Cancer. The Oncologist
7: 539-546
[Abstract][Full Text]
Buchholz, T. A., Kronowitz, S. J., Kuerer, H. M.
(2002). Immediate Breast Reconstruction after Skin-Sparing Mastectomy for the Treatment of Advanced Breast Cancer: Radiation Oncology Considerations. Ann. Surg. Oncol.
9: 820-821
[Full Text]
Chen, H. H. W., Su, W.-C., Guo, H.-R., Chang, T.-W., Lee, W.-Y.
(2002). p53 and c-erbB-2 but Not bcl-2 are Predictive of Metastasis-free Survival in Breast Cancer Patients Receiving Post-mastectomy Adjuvant Radiotherapy in Taiwan. Jpn J Clin Oncol
32: 332-339
[Abstract][Full Text]
Arriagada, R., Le, M. G., Contesso, G., Guinebretiere, J. M., Rochard, F., Spielmann, M.
(2002). Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer. Ann Oncol
13: 1404-1413
[Abstract][Full Text]
Fisher, B., Jeong, J.-H., Anderson, S., Bryant, J., Fisher, E. R., Wolmark, N.
(2002). Twenty-Five-Year Follow-up of a Randomized Trial Comparing Radical Mastectomy, Total Mastectomy, and Total Mastectomy Followed by Irradiation. NEJM
347: 567-575
[Abstract][Full Text]
Stathopoulou, A., Vlachonikolis, I., Mavroudis, D., Perraki, M., Kouroussis, Ch., Apostolaki, S., Malamos, N., Kakolyris, S., Kotsakis, A., Xenidis, N., Reppa, D., Georgoulias, V.
(2002). Molecular Detection of Cytokeratin-19-Positive Cells in the Peripheral Blood of Patients With Operable Breast Cancer: Evaluation of Their Prognostic Significance. JCO
20: 3404-3412
[Abstract][Full Text]
Lee, J. H., Glick, H. A., Hayman, J. A., Solin, L. J.
(2002). Decision-Analytic Model and Cost-Effectiveness Evaluation of Postmastectomy Radiation Therapy in High-Risk Premenopausal Breast Cancer Patients. JCO
20: 2713-2725
[Abstract][Full Text]
Wolff, A. C., Davidson, N. E.
(2002). Preoperative Therapy in Breast Cancer: Lessons from the Treatment of Locally Advanced Disease. The Oncologist
7: 239-245
[Abstract][Full Text]
Vallis, K. A., Pintilie, M., Chong, N., Holowaty, E., Douglas, P. S., Kirkbride, P., Wielgosz, A.
(2002). Assessment of Coronary Heart Disease Morbidity and Mortality After Radiation Therapy for Early Breast Cancer. JCO
20: 1036-1042
[Abstract][Full Text]
Nieto, Y., Nawaz, S., Jones, R. B., Shpall, E. J., Cagnoni, P. J., McSweeney, P. A., Baron, A., Razook, C., Matthes, S., Bearman, S. I.
(2002). Prognostic Model for Relapse After High-Dose Chemotherapy With Autologous Stem-Cell Transplantation for Stage IV Oligometastatic Breast Cancer. JCO
20: 707-718
[Abstract][Full Text]
Buchholz, T. A., Tucker, S. L., Masullo, L., Kuerer, H. M., Erwin, J., Salas, J., Frye, D., Strom, E. A., McNeese, M. D., Perkins, G., Katz, A., Singletary, S. E., Hunt, K. K., Buzdar, A. U., Hortobagyi, G. N.
(2002). Predictors of Local-Regional Recurrence After Neoadjuvant Chemotherapy and Mastectomy Without Radiation. JCO
20: 17-23
[Abstract][Full Text]
Eubank, W. B., Mankoff, D. A., Vesselle, H. J., Eary, J. F., Schubert, E. K., Dunnwald, L. K., Lindsley, S. K., Gralow, J. R., Austin-Seymour, M. M., Ellis, G. K., Livingston, R. B.
(2002). Detection of Locoregional and Distant Recurrences in Breast Cancer Patients by Using FDG PET. RadioGraphics
22: 5-17
[Abstract][Full Text]
Pierce, L. J.
(2001). Treatment Guidelines and Techniques in Delivery of Postmastectomy Radiotherapy in Management of Operable Breast Cancer. J Natl Cancer Inst Monogr
2001: 117-124
[Abstract][Full Text]
Bartelink, H., Horiot, J.-C., Poortmans, P., Struikmans, H., Van den Bogaert, W., Barillot, I., Fourquet, A., Borger, J., Jager, J., Hoogenraad, W., Collette, L., Pierart, M., the European Organization for Research and Treatme,
(2001). Recurrence Rates after Treatment of Breast Cancer with Standard Radiotherapy with or without Additional Radiation. NEJM
345: 1378-1387
[Abstract][Full Text]
Leonard, R., Hardy, J., van Tienhoven, G., Houston, S., Simmonds, P., David, M., Mansi, J.
(2001). Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of 6% Miltefosine Solution, a Topical Chemotherapy in Cutaneous Metastases From Breast Cancer. JCO
19: 4150-4159
[Abstract][Full Text]
Lin, K. Y., Johns, F. R., Gibson, J., Long, M., Drake, D. B., Moore, M. M.
(2001). An Outcome Study of Breast Reconstruction: Presurgical Identification of Risk Factors for Complications. Ann. Surg. Oncol.
8: 586-591
[Abstract][Full Text]
Eubank, W. B., Mankoff, D. A., Takasugi, J., Vesselle, H., Eary, J. F., Shanley, T. J., Gralow, J. R., Charlop, A., Ellis, G. K., Lindsley, K. L., Austin-Seymour, M. M., Funkhouser, C. P., Livingston, R. B.
(2001). 18Fluorodeoxyglucose Positron Emission Tomography to Detect Mediastinal or Internal Mammary Metastases in Breast Cancer. JCO
19: 3516-3523
[Abstract][Full Text]
