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Volume 337:1172-1174 October 16, 1997 Number 16
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Chemotherapy for AIDS-Related Lymphomas

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 by Fisher, R. I.
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 by Kaplan, L. D.
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To the Editor: Kaplan et al. (June 5 issue)1 "recommend that low-dose chemotherapy be considered for most patients with HIV [human immunodeficiency virus] infection and non-Hodgkin's lymphoma," but their results do not convincingly support a general recommendation to use low-dose chemotherapy in patients with high CD4+ counts. Higher CD4+ counts are associated with significantly more complete responses and longer median survival, but in this trial, patients were not stratified according to CD4+ count.2 Although the authors controlled for the absolute CD4+ count in the analysis of survival, the primary end point, and found no difference between the treatment groups, the . . . [Full Text of this Article]

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