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Previous Volume 337:1309-1313 October 30, 1997 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The U.S. Food and Drug Administration has approved recombinant tissue plasminogen activator for the treatment of acute ischemic stroke, but the safety and efficacy of this therapy are still under scrutiny. Should thrombolytic therapy now be used routinely for acute ischemic stroke? Caplan et al. and Grotta present two points of view.

Thrombolysis with intravenous recombinant tissue plasminogen activator (t-PA) has quickly become part of the emergency care of patients with stroke. In December 1995, the report of a trial sponsored jointly by the National Institute of Neurological Disorders and Stroke (NINDS) and Genentech appeared in the Journal.¹ Shortly thereafter, . . . [Full Text of this Article]

Address reprint requests to Dr. Grotta at the Department of Neurology, University of Texas Medical School–Houston, 6431 Fannin, Suite 7044, Houston, TX 77030.

Related Letters:

Should Thrombolytic Therapy Be the First-Line Treatment for Acute Ischemic Stroke?
Kirshner H. S., Schneck M. J., D'Addesio J. P., Caplan L. R., Grotta J.
Extract | Full Text  
N Engl J Med 1998; 338:761-763, Mar 12, 1998. Correspondence

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