Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities

doi:10.1056/NEJM199711063371906

Volume 337:1360-1369		November 6, 1997		Number 19

Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities

Eugene Braunwald, M.D.

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Tthe end of every century it is customary to reflect on theevents of the past hundred years and to look toward the future,and in this lecture I should like to do this for cardiovasculardisease. This is also an especially opportune time to commenton progress in cardiovascular disease, because both the NationalHeart, Lung, and Blood Institute and the American Heart Associationare celebrating their golden anniversaries within the next 18months. These two organizations have had the most profound influenceon the development of research on cardiovascular disease duringthe 20th century.

A bewildering amount of . . . [Full Text of this Article]

Phase 1: The Pandemic of Cardiovascular Disease Emerges

Phase 2: The Battle is Joined

Myocardial Infarction

Development of Procedures and Devices

Importance of Platelets and Their Inhibition by Aspirin

Hypertension

Hypercholesterolemia

A Perspective on Phase 2

Phase 3: The War Has Not Yet Been Won

Inadequate Knowledge

Inadequate Use of Established Strategies

Inadequacies of Established Strategies

Emergence of New Epidemics of Cardiovascular Disease

Phase 4: We Can Prevail

New Risk Factors for Coronary Heart Disease

Advances in Cardiac Imaging

Molecular Approaches to Vascular Disease

Transgenic Techniques

Advances in Molecular Genetics

Gene Transfer

Conclusions

Source Information

From Partners Health Care System and the Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston. Presented as the 107th Shattuck Lecture to the Annual Meeting of the Massachusetts Medical Society, Boston, May 17, 1997.

Address reprint requests to Dr. Braunwald at Prudential Tower, Suite 1150, 800 Boylston St., Boston, MA 02199-8001.

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van Campen, C M C, Visser, F C, de Cock, C C, Vos, H S, Kamp, O, Visser, C A (2006). Comparison of the haemodynamics of different pacing sites in patients undergoing resynchronisation treatment: need for individualisation of lead localisation. Heart 92: 1795-1800 [Abstract] [Full Text]
Kooistra, T., Verschuren, L., de Vries-van der Weij, J., Koenig, W., Toet, K., Princen, H.M.G., Kleemann, R. (2006). Fenofibrate Reduces Atherogenesis in ApoE*3Leiden Mice: Evidence for Multiple Antiatherogenic Effects Besides Lowering Plasma Cholesterol. Arterioscler. Thromb. Vasc. Bio. 26: 2322-2330 [Abstract] [Full Text]
Assmus, B., Honold, J., Schachinger, V., Britten, M. B., Fischer-Rasokat, U., Lehmann, R., Teupe, C., Pistorius, K., Martin, H., Abolmaali, N. D., Tonn, T., Dimmeler, S., Zeiher, A. M. (2006). Transcoronary transplantation of progenitor cells after myocardial infarction.. NEJM 355: 1222-1232 [Abstract] [Full Text]
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Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: e247-e346 [Full Text]
Unwin, N. (2006). The metabolic syndrome. JRSM 99: 457-462 [Full Text]
Zipes, D. P., Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA (Practice Guidelines) Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society.. Eur Heart J 27: 2099-2140 [Full Text]
Writing Committee Members, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 8: 746-837 [Full Text]
Olson, T. M., Alekseev, A. E., Liu, X. K., Park, S., Zingman, L. V., Bienengraeber, M., Sattiraju, S., Ballew, J. D., Jahangir, A., Terzic, A. (2006). Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet 15: 2185-2191 [Abstract] [Full Text]
Kehat, I., Heinrich, R., Ben-Izhak, O., Miyazaki, H., Gutkind, J. S., Aronheim, A. (2006). Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation. Cardiovasc Res 70: 543-554 [Abstract] [Full Text]
Battaglia, M., Pewsner, D., Juni, P., Egger, M., Bucher, H. C., Bachmann, L. M. (2006). Accuracy of B-type natriuretic Peptide tests to exclude congestive heart failure: systematic review of test accuracy studies.. Arch Intern Med 166: 1073-1080 [Abstract] [Full Text]
Hanna, I. R., Heeke, B., Bush, H., Brosius, L., King-Hageman, D., Beshai, J. F., Langberg, J. J. (2006). The Relationship Between Stature and the Prevalence of Atrial Fibrillation in Patients With Left Ventricular Dysfunction. J Am Coll Cardiol 47: 1683-1688 [Abstract] [Full Text]
Henry, T. D., Atkins, J. M., Cunningham, M. S., Francis, G. S., Groh, W. J., Hong, R. A., Kern, K. B., Larson, D. M., Ohman, E. M., Ornato, J. P., Peberdy, M. A., Rosenberg, M. J., Weaver, W. D. (2006). ST-Segment Elevation Myocardial Infarction: Recommendations on Triage of Patients to Heart Attack Centers: Is it Time for a National Policy for the Treatment of ST-Segment Elevation Myocardial Infarction?. J Am Coll Cardiol 47: 1339-1345 [Abstract] [Full Text]
Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W., Seward, J. B., Iwasaka, T., Tsang, T. S.M. (2006). Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades. Eur Heart J 27: 936-941 [Abstract] [Full Text]
Popovic, Z. B., Prasad, A., Garcia, M. J., Arbab-Zadeh, A., Borowski, A., Dijk, E., Greenberg, N. L., Levine, B. D., Thomas, J. D. (2006). Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness. Am. J. Physiol. Heart Circ. Physiol. 290: H1454-H1459 [Abstract] [Full Text]
Mu, H., Ohashi, R., Yan, S., Chai, H., Yang, H., Lin, P., Yao, Q., Chen, C. (2006). Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res 70: 146-157 [Abstract] [Full Text]
Barker, W. H., Mullooly, J. P., Getchell, W. (2006). Changing Incidence and Survival for Heart Failure in a Well-Defined Older Population, 1970-1974 and 1990-1994. Circulation 113: 799-805 [Abstract] [Full Text]
Cordero, A, Alegria, E (2006). Sex differences and cardiovascular risk. Heart 92: 145-146 [Abstract] [Full Text]
Witt, B. J., Brown, R. D. Jr., Jacobsen, S. J., Weston, S. A., Yawn, B. P., Roger, V. L. (2005). A Community-Based Study of Stroke Incidence after Myocardial Infarction. ANN INTERN MED 143: 785-792 [Abstract] [Full Text]
Witte, K. K.A., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H.-D., Anker, S. D., Clark, A. L., Cleland, J. G.F. (2005). The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 26: 2238-2244 [Abstract] [Full Text]
Wang, C. S., FitzGerald, J. M., Schulzer, M., Mak, E., Ayas, N. T. (2005). Does This Dyspneic Patient in the Emergency Department Have Congestive Heart Failure?. JAMA 294: 1944-1956 [Abstract] [Full Text]
Andraws, R., Berger, J. S., Brown, D. L. (2005). Effects of Antibiotic Therapy on Outcomes of Patients With Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials. JAMA 293: 2641-2647 [Abstract] [Full Text]
Burkhoff, D., Ben-Haim, S. A. (2005). Nonexcitatory electrical signals for enhancing ventricular contractility: rationale and initial investigations of an experimental treatment for heart failure. Am. J. Physiol. Heart Circ. Physiol. 288: H2550-H2556 [Full Text]
Katira, R, Chauhan, A, More, R S (2005). Direct thrombin inhibitors: novel antithrombotics on the horizon in the thromboprophylactic management of atrial fibrillation. Postgrad. Med. J. 81: 370-375 [Abstract] [Full Text]
Raju, S. V. Y., Barouch, L. A., Hare, J. M. (2005). Nitric Oxide and Oxidative Stress in Cardiovascular Aging. Sci Aging Knowl Environ 2005: re4-re4 [Abstract] [Full Text]
Gersh, B. J., Tsang, T. S.M., Barnes, M. E., Seward, J. B. (2005). The changing epidemiology of non-valvular atrial fibrillation: the role of novel risk factors. Eur Heart J Suppl 7: C5-C11 [Abstract] [Full Text]
Falcone, C., Emanuele, E., D'Angelo, A., Buzzi, M. P., Belvito, C., Cuccia, M., Geroldi, D. (2005). Plasma Levels of Soluble Receptor for Advanced Glycation End Products and Coronary Artery Disease in Nondiabetic Men. Arterioscler. Thromb. Vasc. Bio. 25: 1032-1037 [Abstract] [Full Text]
Lau, D. C. W., Dhillon, B., Yan, H., Szmitko, P. E., Verma, S. (2005). Adipokines: molecular links between obesity and atheroslcerosis. Am. J. Physiol. Heart Circ. Physiol. 288: H2031-H2041 [Abstract] [Full Text]
Mikkelsson, J., Perola, M., Karhunen, P. J. (2005). Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications. CLIN APPL THROMB HEMOST 11: 113-125 [Abstract]
Rasul, F, Stansfeld, S A, Hart, C L, Davey Smith, G (2005). Psychological distress, physical illness, and risk of coronary heart disease. J. Epidemiol. Community Health 59: 140-145 [Abstract] [Full Text]
Bursi, F., Enriquez-Sarano, M., Nkomo, V. T., Jacobsen, S. J., Weston, S. A., Meverden, R. A., Roger, V. L. (2005). Heart Failure and Death After Myocardial Infarction in the Community: The Emerging Role of Mitral Regurgitation. Circulation 111: 295-301 [Abstract] [Full Text]
Grigioni, F., Detaint, D., Avierinos, J.-F., Scott, C., Tajik, J., Enriquez-Sarano, M. (2005). Contribution of ischemic mitral regurgitation to congestive heart failure after myocardial infarction. J Am Coll Cardiol 45: 260-267 [Abstract] [Full Text]
Davi, G., Neri, M., Falco, A., Festi, D., Taraborelli, T., Ciabattoni, G., Basili, S., Cuccurullo, F., Patrono, C. (2005). Helicobacter Pylori Infection Causes Persistent Platelet Activation In Vivo Through Enhanced Lipid Peroxidation. Arterioscler. Thromb. Vasc. Bio. 25: 246-251 [Abstract] [Full Text]
Hsu, L.-F., Jais, P., Sanders, P., Garrigue, S., Hocini, M., Sacher, F., Takahashi, Y., Rotter, M., Pasquie, J.-L., Scavee, C., Bordachar, P., Clementy, J., Haissaguerre, M. (2004). Catheter Ablation for Atrial Fibrillation in Congestive Heart Failure. NEJM 351: 2373-2383 [Abstract] [Full Text]
Kampschulte, A., Ferguson, M.S., Kerwin, W.S., Polissar, N. L., Chu, B., Saam, T., Hatsukami, T.S., Yuan, C. (2004). Differentiation of Intraplaque Versus Juxtaluminal Hemorrhage/Thrombus in Advanced Human Carotid Atherosclerotic Lesions by In Vivo Magnetic Resonance Imaging. Circulation 110: 3239-3244 [Abstract] [Full Text]
Young, J. B., Dunlap, M. E., Pfeffer, M. A., Probstfield, J. L., Cohen-Solal, A., Dietz, R., Granger, C. B., Hradec, J., Kuch, J., McKelvie, R. S., McMurray, J. J.V., Michelson, E. L., Olofsson, B., Ostergren, J., Held, P., Solomon, S. D., Yusuf, S., Swedberg, K., for the Candesartan in Heart failure Assessment of, (2004). Mortality and Morbidity Reduction With Candesartan in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction: Results of the CHARM Low-Left Ventricular Ejection Fraction Trials. Circulation 110: 2618-2626 [Abstract] [Full Text]
Ornstein, S., Jenkins, R. G., Nietert, P. J., Feifer, C., Roylance, L. F., Nemeth, L., Corley, S., Dickerson, L., Bradford, W. D., Litvin, C. (2004). A Multimethod Quality Improvement Intervention To Improve Preventive Cardiovascular Care: A Cluster Randomized Trial. ANN INTERN MED 141: 523-532 [Abstract] [Full Text]
Recinos, A. III, Carr, B. K., Bartos, D. B., Boldogh, I., Carmical, J. R., Belalcazar, L. M., Brasier, A. R. (2004). Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiol. Genomics 19: 131-142 [Abstract] [Full Text]
Lloyd-Jones, D. M., Wang, T. J., Leip, E. P., Larson, M. G., Levy, D., Vasan, R. S., D'Agostino, R. B., Massaro, J. M., Beiser, A., Wolf, P. A., Benjamin, E. J. (2004). Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study. Circulation 110: 1042-1046 [Abstract] [Full Text]
Wientgen, H., Thorngate, F. E., Omerhodzic, S., Rolnitzky, L., Fallon, J. T., Williams, D. L., Fisher, E. A. (2004). Subphysiologic Apolipoprotein E (ApoE) Plasma Levels Inhibit Neointimal Formation After Arterial Injury in ApoE-Deficient Mice. Arterioscler. Thromb. Vasc. Bio. 24: 1460-1465 [Abstract] [Full Text]
Gami, A. S., Pressman, G., Caples, S. M., Kanagala, R., Gard, J. J., Davison, D. E., Malouf, J. F., Ammash, N. M., Friedman, P. A., Somers, V. K. (2004). Association of Atrial Fibrillation and Obstructive Sleep Apnea. Circulation 110: 364-367 [Abstract] [Full Text]
Roger, V. L., Weston, S. A., Redfield, M. M., Hellermann-Homan, J. P., Killian, J., Yawn, B. P., Jacobsen, S. J. (2004). Trends in Heart Failure Incidence and Survival in a Community-Based Population. JAMA 292: 344-350 [Abstract] [Full Text]
L'Allier, P. L., Ducharme, A., Keller, P.-F., Yu, H., Guertin, M.-C., Tardif, J.-C. (2004). Angiotensin-converting enzyme inhibition in hypertensive patients is associated with a reduction in the occurrence of atrial fibrillation. J Am Coll Cardiol 44: 159-164 [Abstract] [Full Text]
Cha, Y.-M., Redfield, M. M., Shen, W.-K., Gersh, B. J. (2004). Atrial Fibrillation and Ventricular Dysfunction: A Vicious Electromechanical Cycle. Circulation 109: 2839-2843 [Full Text]
Pasternak, R. C., Criqui, M. H., Benjamin, E. J., Fowkes, F. G. R., Isselbacher, E. M., McCullough, P. A., Wolf, P. A., Zheng, Z.-J. (2004). Atherosclerotic Vascular Disease Conference: Writing Group I: Epidemiology. Circulation 109: 2605-2612 [Full Text]
Willerson, J. T., Ridker, P. M. (2004). Inflammation as a Cardiovascular Risk Factor. Circulation 109: II-2-II-10 [Abstract] [Full Text]
Arking, D. E., Chugh, S. S., Chakravarti, A., Spooner, P. M. (2004). Genomics in Sudden Cardiac Death. Circ. Res. 94: 712-723 [Abstract] [Full Text]
Zhang, R., Ma, J., Xia, M., Zhu, H., Ling, W. (2004). Mild Hyperhomocysteinemia Induced by Feeding Rats Diets Rich in Methionine or Deficient in Folate Promotes Early Atherosclerotic Inflammatory Processes. J. Nutr. 134: 825-830 [Abstract] [Full Text]
Levy, D., Kannel, W. B. (2004). Postoperative atrial fibrillation and mortality: do the risks merit changes in clinical practice?. J Am Coll Cardiol 43: 749-751 [Full Text]
Alexaki, A., Wilson, T. A., Atallah, M. T., Handelman, G., Nicolosi, R. J. (2004). Hamsters Fed Diets High in Saturated Fat Have Increased Cholesterol Accumulation and Cytokine Production in the Aortic Arch Compared with Cholesterol-Fed Hamsters with Moderately Elevated Plasma Non-HDL Cholesterol Concentrations. J. Nutr. 134: 410-415 [Abstract] [Full Text]
Boos, C.J., Carlsson, J., More, R.S. (2003). Rate or rhythm control in persistent atrial fibrillation?. QJM 96: 881-892 [Abstract] [Full Text]
Cesari, M., Penninx, B. W.J.H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Rubin, S. M., Ding, J., Simonsick, E. M., Harris, T. B., Pahor, M. (2003). Inflammatory Markers and Onset of Cardiovascular Events: Results From the Health ABC Study. Circulation 108: 2317-2322 [Abstract] [Full Text]
Andresdottir, M. B., Sigfusson, N., Sigvaldason, H., Gudnason, V. (2003). Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and Women: The Reykjavik Study. Am J Epidemiol 158: 844-851 [Abstract] [Full Text]

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