FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 337:1360-1369 November 6, 1997 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Tthe end of every century it is customary to reflect on the events of the past hundred years and to look toward the future, and in this lecture I should like to do this for cardiovascular disease. This is also an especially opportune time to comment on progress in cardiovascular disease, because both the National Heart, Lung, and Blood Institute and the American Heart Association are celebrating their golden anniversaries within the next 18 months. These two organizations have had the most profound influence on the development of research on cardiovascular disease during the 20th century.

A bewildering amount of . . . [Full Text of this Article]

Phase 1: The Pandemic of Cardiovascular Disease Emerges

Phase 2: The Battle is Joined

Myocardial Infarction

Development of Procedures and Devices

Importance of Platelets and Their Inhibition by Aspirin

Hypertension

Hypercholesterolemia

A Perspective on Phase 2

Phase 3: The War Has Not Yet Been Won

Inadequate Knowledge

Inadequate Use of Established Strategies

Inadequacies of Established Strategies

Emergence of New Epidemics of Cardiovascular Disease

Phase 4: We Can Prevail

New Risk Factors for Coronary Heart Disease

Advances in Cardiac Imaging

Molecular Approaches to Vascular Disease

Transgenic Techniques

Advances in Molecular Genetics

Gene Transfer

Conclusions

Source Information

From Partners Health Care System and the Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston. Presented as the 107th Shattuck Lecture to the Annual Meeting of the Massachusetts Medical Society, Boston, May 17, 1997.

Address reprint requests to Dr. Braunwald at Prudential Tower, Suite 1150, 800 Boylston St., Boston, MA 02199-8001.

References

Related Letters:

Cardiovascular Medicine at the Turn of the Millennium
Plump A., Ketterer M. W.
Extract | Full Text  
N Engl J Med 1998; 338:919-920, Mar 26, 1998. Correspondence

This article has been cited by other articles:

• Duchene, J., Cayla, C., Vessillier, S., Scotland, R., Yamashiro, K., Lecomte, F., Syed, I., Vo, P., Marrelli, A., Pitzalis, C., Cipollone, F., Schanstra, J., Bascands, J.-L., Hobbs, A. J., Perretti, M., Ahluwalia, A. (2009). Laminar Shear Stress Regulates Endothelial Kinin B1 Receptor Expression and Function: Potential Implication in Atherogenesis. Arterioscler. Thromb. Vasc. Bio. 29: 1757-1763 [Abstract] [Full Text]  
• Brauch, K. M., Karst, M. L., Herron, K. J., de Andrade, M., Pellikka, P. A., Rodeheffer, R. J., Michels, V. V., Olson, T. M. (2009). Mutations in ribonucleic Acid binding protein gene cause familial dilated cardiomyopathy.. J Am Coll Cardiol 54: 930-941 [Abstract] [Full Text]  
• Krumholz, H. M., Wang, Y., Chen, J., Drye, E. E., Spertus, J. A., Ross, J. S., Curtis, J. P., Nallamothu, B. K., Lichtman, J. H., Havranek, E. P., Masoudi, F. A., Radford, M. J., Han, L. F., Rapp, M. T., Straube, B. M., Normand, S.-L. T. (2009). Reduction in Acute Myocardial Infarction Mortality in the United States: Risk-Standardized Mortality Rates From 1995-2006. JAMA 302: 767-773 [Abstract] [Full Text]  
• Simanek, A. M, Dowd, J. B., Aiello, A. E (2009). Persistent pathogens linking socioeconomic position and cardiovascular disease in the US. Int J Epidemiol 38: 775-787 [Abstract] [Full Text]  
• Anter, E., Jessup, M., Callans, D. J. (2009). Atrial Fibrillation and Heart Failure: Treatment Considerations for a Dual Epidemic. Circulation 119: 2516-2525 [Full Text]  
• Najafi, F., Jamrozik, K., Dobson, A. J. (2009). Understanding the 'epidemic of heart failure': a systematic review of trends in determinants of heart failure. Eur J Heart Fail 11: 472-479 [Abstract] [Full Text]  
• Tzanetos, K., Leong, D., Wu, R. C. (2009). Office management of patients with diastolic heart failure. CMAJ 180: 520-527 [Full Text]  
• Fuster, V., van der Zee, S., Elmariah, S., Bonow, R. O. (2009). Academic Careers in Cardiovascular Medicine. Circulation 119: 754-760 [Full Text]  
• Roger, V. L. (2009). Severity of Myocardial Infarction: New Insights on an Elusive Construct. Circulation 119: 489-491 [Full Text]  
• Verschuren, L., de Vries-van der Weij, J., Zadelaar, S., Kleemann, R., Kooistra, T. (2009). LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms. J. Lipid Res. 50: 301-311 [Abstract] [Full Text]  
• Hingorani, A. D., Shah, T., Casas, J. P., Humphries, S. E., Talmud, P. J. (2009). C-Reactive Protein and Coronary Heart Disease: Predictive Test or Therapeutic Target?. Clin. Chem. 55: 239-255 [Abstract] [Full Text]  
• Kaneda, R., Takada, S., Yamashita, Y., Choi, Y. L., Nonaka-Sarukawa, M., Soda, M., Misawa, Y., Isomura, T., Shimada, K., Mano, H. (2009). Genome-wide histone methylation profile for heart failure. GENES CELLS 14: 69-77 [Abstract] [Full Text]  
• Myerburg, R. J. (2008). Implantable Cardioverter-Defibrillators after Myocardial Infarction. NEJM 359: 2245-2253 [Full Text]  
• Tsang, T. S.M., Barnes, M. E., Miyasaka, Y., Cha, S. S., Bailey, K. R., Verzosa, G. C., Seward, J. B., Gersh, B. J. (2008). Obesity as a risk factor for the progression of paroxysmal to permanent atrial fibrillation: a longitudinal cohort study of 21 years. Eur Heart J 29: 2227-2233 [Abstract] [Full Text]  
• Gikas, A., Sotiropoulos, A., Panagiotakos, D., Pastromas, V., Papazafiropoulou, A., Pappas, S. (2008). Prevalence trends for myocardial infarction and conventional risk factors among Greek adults (2002-06). QJM 101: 705-712 [Abstract] [Full Text]  
• Garza, C. A., Pellikka, P. A., Somers, V. K., Sarr, M. G., Seward, J. B., Collazo-Clavell, M. L., Oehler, E., Lopez-Jimenez, F. (2008). Major weight loss prevents long-term left atrial enlargement in patients with morbid and extreme obesity. Eur J Echocardiogr 9: 587-593 [Abstract] [Full Text]  
• Fang, J., Mensah, G. A., Croft, J. B., Keenan, N. L. (2008). Heart Failure-Related Hospitalization in the U.S., 1979 to 2004. J Am Coll Cardiol 52: 428-434 [Abstract] [Full Text]  
• Najafi, F., Dobson, A. J., Hobbs, M., Jamrozik, K. (2008). Late-onset heart failure after myocardial infarction: Trends in incidence and survival. Eur J Heart Fail 10: 765-771 [Abstract] [Full Text]  
• Thorp, E., Cui, D., Schrijvers, D. M., Kuriakose, G., Tabas, I. (2008). Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe-/- Mice. Arterioscler. Thromb. Vasc. Bio. 28: 1421-1428 [Abstract] [Full Text]  
• Hodgson-Zingman, D. M., Karst, M. L., Zingman, L. V., Heublein, D. M., Darbar, D., Herron, K. J., Ballew, J. D., de Andrade, M., Burnett, J. C. Jr., Olson, T. M. (2008). Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation. NEJM 359: 158-165 [Abstract] [Full Text]  
• Roy, D., Talajic, M., Nattel, S., Wyse, D. G., Dorian, P., Lee, K. L., Bourassa, M. G., Arnold, J. M. O., Buxton, A. E., Camm, A. J., Connolly, S. J., Dubuc, M., Ducharme, A., Guerra, P. G., Hohnloser, S. H., Lambert, J., Le Heuzey, J.-Y., O'Hara, G., Pedersen, O. D., Rouleau, J.-L., Singh, B. N., Stevenson, L. W., Stevenson, W. G., Thibault, B., Waldo, A. L., the Atrial Fibrillation and Congestive Heart Failu, (2008). Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure. NEJM 358: 2667-2677 [Abstract] [Full Text]  
• Meng, L, Lv, B, Zhang, S, Yv, B (2008). In vivo optical coherence tomography of experimental thrombosis in a rabbit carotid model. Heart 94: 777-780 [Abstract] [Full Text]  
• Lutomsky, B. A., Rostock, T., Koops, A., Steven, D., Mullerleile, K., Servatius, H., Drewitz, I., Ueberschar, D., Plagemann, T., Ventura, R., Meinertz, T., Willems, S. (2008). Catheter ablation of paroxysmal atrial fibrillation improves cardiac function: a prospective study on the impact of atrial fibrillation ablation on left ventricular function assessed by magnetic resonance imaging. Europace 10: 593-599 [Abstract] [Full Text]  
• Adya, R., Tan, B. K., Punn, A., Chen, J., Randeva, H. S. (2008). Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res 78: 356-365 [Abstract] [Full Text]  
• Saxena, A., Fish, J. E., White, M. D., Yu, S., Smyth, J. W.P., Shaw, R. M., DiMaio, J. M., Srivastava, D. (2008). Stromal Cell-Derived Factor-1{alpha} Is Cardioprotective After Myocardial Infarction. Circulation 117: 2224-2231 [Abstract] [Full Text]  
• Wung, S.-F., Aouizerat, B. E. (2008). Candidate Genes of the 5-Lipoxygenase Pathway in Acute Coronary Syndrome: A Pilot Study. Biol Res Nurs 9: 280-292 [Abstract]  
• Adya, R., Tan, B. K., Chen, J., Randeva, H. S. (2008). Nuclear Factor-{kappa}B Induction by Visfatin in Human Vascular Endothelial Cells: Its role in MMP-2/9 production and activation. Diabetes Care 31: 758-760 [Abstract] [Full Text]  
• Schenker, M. P., Dorbala, S., Hong, E. C. T., Rybicki, F. J., Hachamovitch, R., Kwong, R. Y., Di Carli, M. F. (2008). Interrelation of Coronary Calcification, Myocardial Ischemia, and Outcomes in Patients With Intermediate Likelihood of Coronary Artery Disease: A Combined Positron Emission Tomography/Computed Tomography Study. Circulation 117: 1693-1700 [Abstract] [Full Text]  
• Rossi, R., Nuzzo, A., Origliani, G., Modena, M. G. (2008). Prognostic role of flow-mediated dilation and cardiac risk factors in post-menopausal women.. J Am Coll Cardiol 51: 997-1002 [Abstract] [Full Text]  
• Padera, R. F. Jr., Schoen, F. J. (2008). Pathology of Cardiac Surgery. Card Surg Adult 3: 111-178 [Full Text]  
• Voeller, R. K., Schuessler, R. B., Damiano, R. J. Jr. (2008). Surgical Treatment of Atrial Fibrillation. Card Surg Adult 3: 1375-1394 [Full Text]  
• Ruchat, P., Virag, N., Dang, L., Schlaepfer, J., Pruvot, E., Kappenberger, L. (2007). A biophysical model of atrial fibrillation ablation: what can a surgeon learn from a computer model?. Europace 9: vi71-vi76 [Abstract] [Full Text]  
• Gortney, J. S., Sanders, R. M. (2007). Impact of C-reactive protein on treatment of patients with cardiovascular disease. Am J Health Syst Pharm 64: 2009-2016 [Abstract] [Full Text]  
• Najafi, F., Dobson, A. J., Hobbs, M., Jamrozik, K. (2007). Temporal trends in the frequency and longer-term outcome of heart failure complicating myocardial infarction. Eur J Heart Fail 9: 879-885 [Abstract] [Full Text]  
• Miyasaka, Y., Barnes, M. E., Petersen, R. C., Cha, S. S., Bailey, K. R., Gersh, B. J., Casaclang-Verzosa, G., Abhayaratna, W. P., Seward, J. B., Iwasaka, T., Tsang, T. S.M. (2007). Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort. Eur Heart J 28: 1962-1967 [Abstract] [Full Text]  
• Ruchat, P., Dang, L., Schlaepfer, J., Virag, N., von Segesser, L. K., Kappenberger, L. (2007). Use of a biophysical model of atrial fibrillation in the interpretation of the outcome of surgical ablation procedures. Eur. J. Cardiothorac. Surg. 32: 90-95 [Abstract] [Full Text]  
• Authors/Task Force Members, , Ryden, L., Standl, E., Bartnik, M., Berghe, G. V. d., Betteridge, J., de Boer, M.-J., Cosentino, F., Jonsson, B., Laakso, M., Malmberg, K., Priori, S., Ostergren, J., Tuomilehto, J., Thrainsdottir, I., Other Contributors, , Vanhorebeek, I., Stramba-Badiale, M., Lindgren, P., Qiao, Q., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Deckers, J. W., Bertrand, M., Charbonnel, B., Erdmann, E., Ferrannini, E., Flyvbjerg, A., Gohlke, H., Juanatey, J. R. G., Graham, I., Monteiro, P. F., Parhofer, K., Pyorala, K., Raz, I., Schernthaner, G., Volpe, M., Wood, D. (2007). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J Suppl 9: C3-C74 [Full Text]  
• Eiselein, L., Wilson, D. W., Lame, M. W., Rutledge, J. C. (2007). Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis. Am. J. Physiol. Heart Circ. Physiol. 292: H2745-H2753 [Abstract] [Full Text]  
• Alexander, K. P., Newby, L. K., Armstrong, P. W., Cannon, C. P., Gibler, W. B., Rich, M. W., Van de Werf, F., White, H. D., Weaver, W. D., Naylor, M. D., Gore, J. M., Krumholz, H. M., Ohman, E. M. (2007). Acute Coronary Care in the Elderly, Part II: ST-Segment-Elevation Myocardial Infarction: A Scientific Statement for Healthcare Professionals From the American Heart Association Council on Clinical Cardiology: In Collaboration With the Society of Geriatric Cardiology. Circulation 115: 2570-2589 [Abstract] [Full Text]  
• Rao, S. V., Eikelboom, J. A., Granger, C. B., Harrington, R. A., Califf, R. M., Bassand, J.-P. (2007). Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J 28: 1193-1204 [Abstract] [Full Text]  
• Allen, L. A., O'Connor, C. M. (2007). Management of acute decompensated heart failure. CMAJ 176: 797-805 [Abstract] [Full Text]  
• Goldberg, R. J., Ciampa, J., Lessard, D., Meyer, T. E., Spencer, F. A. (2007). Long-term Survival After Heart Failure: A Contemporary Population-Based Perspective. Arch Intern Med 167: 490-496 [Abstract] [Full Text]  
• Miyasaka, Y., Barnes, M. E., Bailey, K. R., Cha, S. S., Gersh, B. J., Seward, J. B., Tsang, T. S.M. (2007). Mortality Trends in Patients Diagnosed With First Atrial Fibrillation: A 21-Year Community-Based Study. J Am Coll Cardiol 49: 986-992 [Abstract] [Full Text]  
• Tafreshi, M. J., Rowles, J. (2007). A Review of the Investigational Antiarrhythmic Agent Dronedarone. J CARDIOVASC PHARMACOL THER 12: 15-26 [Abstract]  
• Gami, A. S., Hodge, D. O., Herges, R. M., Olson, E. J., Nykodym, J., Kara, T., Somers, V. K. (2007). Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation. J Am Coll Cardiol 49: 565-571 [Abstract] [Full Text]  
• Goff, D. C. Jr, Brass, L., Braun, L. T., Croft, J. B., Flesch, J. D., Fowkes, F. G.R., Hong, Y., Howard, V., Huston, S., Jencks, S. F., Luepker, R., Manolio, T., O'Donnell, C., Marie Robertson, R., Rosamond, W., Rumsfeld, J., Sidney, S., Zheng, Z. J. (2007). Essential Features of a Surveillance System to Support the Prevention and Management of Heart Disease and Stroke: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Stroke, and Cardiovascular Nursing and the Interdisciplinary Working Groups on Quality of Care and Outcomes Research and Atherosclerotic Peripheral Vascular Disease. Circulation 115: 127-155 [Full Text]  
• Authors/Task Force Members, , Ryden, L., Standl, E., Bartnik, M., Van den Berghe, G., Betteridge, J., de Boer, M.-J., Cosentino, F., Jonsson, B., Laakso, M., Malmberg, K., Priori, S., Ostergren, J., Tuomilehto, J., Thrainsdottir, I., Other Contributors, , Vanhorebeek, I., Stramba-Badiale, M., Lindgren, P., Qiao, Q., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Deckers, J. W., Bertrand, M., Charbonnel, B., Erdmann, E., Ferrannini, E., Flyvbjerg, A., Gohlke, H., Juanatey, J. R. G., Graham, I., Monteiro, P. F., Parhofer, K., Pyorala, K., Raz, I., Schernthaner, G., Volpe, M., Wood, D. (2007). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 28: 88-136 [Full Text]  
• Ruchat, P., Dang, L., Virag, N., Schlaepfer, J., von Segesser, L. K., Kappenberger, L. (2007). A biophysical model of atrial fibrillation to define the appropriate ablation pattern in modified maze. Eur. J. Cardiothorac. Surg. 31: 65-69 [Abstract] [Full Text]  
• van Campen, C M C, Visser, F C, de Cock, C C, Vos, H S, Kamp, O, Visser, C A (2006). Comparison of the haemodynamics of different pacing sites in patients undergoing resynchronisation treatment: need for individualisation of lead localisation. Heart 92: 1795-1800 [Abstract] [Full Text]  
• Postiglione, L., Montagnani, S., Ladogana, P., Castaldo, C., Di Spigna, G., Bruno, E. M., Turano, M., De Santo, L., Cudemo, G., Cocozza, S., de Divitiis, O., Rossi, G. (2006). Granulocyte Macrophage-Colony Stimulating Factor receptor expression on human cardiomyocytes from end-stage heart failure patients. Eur J Heart Fail 8: 564-570 [Abstract] [Full Text]  
• Kooistra, T., Verschuren, L., de Vries-van der Weij, J., Koenig, W., Toet, K., Princen, H.M.G., Kleemann, R. (2006). Fenofibrate Reduces Atherogenesis in ApoE*3Leiden Mice: Evidence for Multiple Antiatherogenic Effects Besides Lowering Plasma Cholesterol. Arterioscler. Thromb. Vasc. Bio. 26: 2322-2330 [Abstract] [Full Text]  
• Assmus, B., Honold, J., Schachinger, V., Britten, M. B., Fischer-Rasokat, U., Lehmann, R., Teupe, C., Pistorius, K., Martin, H., Abolmaali, N. D., Tonn, T., Dimmeler, S., Zeiher, A. M. (2006). Transcoronary transplantation of progenitor cells after myocardial infarction.. NEJM 355: 1222-1232 [Abstract] [Full Text]  
• Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: 1064-1108 [Full Text]  
• Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: e247-e346 [Full Text]  
• Unwin, N. (2006). The metabolic syndrome. JRSM 99: 457-462 [Full Text]  
• Zipes, D. P., Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA (Practice Guidelines) Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society.. Eur Heart J 27: 2099-2140 [Full Text]  
• Writing Committee Members, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 8: 746-837 [Full Text]  
• van Veldhuisen, D. J., Aass, H., El Allaf, D., Dunselman, P. H.J.M., Gullestad, L., Halinen, M., Kjekshus, J., Ohlsson, L., Wedel, H., Wikstrand, J., MERIT-HF Study Group, (2006). Presence and development of atrial fibrillation in chronic heart failure: Experiences from the MERIT-HF Study. Eur J Heart Fail 8: 539-546 [Abstract] [Full Text]  
• Olson, T. M., Alekseev, A. E., Liu, X. K., Park, S., Zingman, L. V., Bienengraeber, M., Sattiraju, S., Ballew, J. D., Jahangir, A., Terzic, A. (2006). Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet 15: 2185-2191 [Abstract] [Full Text]  
• Kehat, I., Heinrich, R., Ben-Izhak, O., Miyazaki, H., Gutkind, J. S., Aronheim, A. (2006). Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation. Cardiovasc Res 70: 543-554 [Abstract] [Full Text]  
• Battaglia, M., Pewsner, D., Juni, P., Egger, M., Bucher, H. C., Bachmann, L. M. (2006). Accuracy of B-type natriuretic Peptide tests to exclude congestive heart failure: systematic review of test accuracy studies.. Arch Intern Med 166: 1073-1080 [Abstract] [Full Text]  
• Hanna, I. R., Heeke, B., Bush, H., Brosius, L., King-Hageman, D., Beshai, J. F., Langberg, J. J. (2006). The Relationship Between Stature and the Prevalence of Atrial Fibrillation in Patients With Left Ventricular Dysfunction. J Am Coll Cardiol 47: 1683-1688 [Abstract] [Full Text]  
• Henry, T. D., Atkins, J. M., Cunningham, M. S., Francis, G. S., Groh, W. J., Hong, R. A., Kern, K. B., Larson, D. M., Ohman, E. M., Ornato, J. P., Peberdy, M. A., Rosenberg, M. J., Weaver, W. D. (2006). ST-Segment Elevation Myocardial Infarction: Recommendations on Triage of Patients to Heart Attack Centers: Is it Time for a National Policy for the Treatment of ST-Segment Elevation Myocardial Infarction?. J Am Coll Cardiol 47: 1339-1345 [Abstract] [Full Text]  
• Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W., Seward, J. B., Iwasaka, T., Tsang, T. S.M. (2006). Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades. Eur Heart J 27: 936-941 [Abstract] [Full Text]  
• Popovic, Z. B., Prasad, A., Garcia, M. J., Arbab-Zadeh, A., Borowski, A., Dijk, E., Greenberg, N. L., Levine, B. D., Thomas, J. D. (2006). Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness. Am. J. Physiol. Heart Circ. Physiol. 290: H1454-H1459 [Abstract] [Full Text]  
• Mu, H., Ohashi, R., Yan, S., Chai, H., Yang, H., Lin, P., Yao, Q., Chen, C. (2006). Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res 70: 146-157 [Abstract] [Full Text]  
• Barker, W. H., Mullooly, J. P., Getchell, W. (2006). Changing Incidence and Survival for Heart Failure in a Well-Defined Older Population, 1970-1974 and 1990-1994. Circulation 113: 799-805 [Abstract] [Full Text]  
• Cordero, A, Alegria, E (2006). Sex differences and cardiovascular risk. Heart 92: 145-146 [Abstract] [Full Text]  
• Witt, B. J., Brown, R. D. Jr., Jacobsen, S. J., Weston, S. A., Yawn, B. P., Roger, V. L. (2005). A Community-Based Study of Stroke Incidence after Myocardial Infarction. ANN INTERN MED 143: 785-792 [Abstract] [Full Text]  
• Witte, K. K.A., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H.-D., Anker, S. D., Clark, A. L., Cleland, J. G.F. (2005). The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 26: 2238-2244 [Abstract] [Full Text]  
• Wang, C. S., FitzGerald, J. M., Schulzer, M., Mak, E., Ayas, N. T. (2005). Does This Dyspneic Patient in the Emergency Department Have Congestive Heart Failure?. JAMA 294: 1944-1956 [Abstract] [Full Text]  
• Andraws, R., Berger, J. S., Brown, D. L. (2005). Effects of Antibiotic Therapy on Outcomes of Patients With Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials. JAMA 293: 2641-2647 [Abstract] [Full Text]  
• Burkhoff, D., Ben-Haim, S. A. (2005). Nonexcitatory electrical signals for enhancing ventricular contractility: rationale and initial investigations of an experimental treatment for heart failure. Am. J. Physiol. Heart Circ. Physiol. 288: H2550-H2556 [Full Text]  
• Katira, R, Chauhan, A, More, R S (2005). Direct thrombin inhibitors: novel antithrombotics on the horizon in the thromboprophylactic management of atrial fibrillation. Postgrad. Med. J. 81: 370-375 [Abstract] [Full Text]  
• Raju, S. V. Y., Barouch, L. A., Hare, J. M. (2005). Nitric Oxide and Oxidative Stress in Cardiovascular Aging. Sci Aging Knowl Environ 2005: re4-re4 [Abstract] [Full Text]  
• Gersh, B. J., Tsang, T. S.M., Barnes, M. E., Seward, J. B. (2005). The changing epidemiology of non-valvular atrial fibrillation: the role of novel risk factors. Eur Heart J Suppl 7: C5-C11 [Abstract] [Full Text]  
• Falcone, C., Emanuele, E., D'Angelo, A., Buzzi, M. P., Belvito, C., Cuccia, M., Geroldi, D. (2005). Plasma Levels of Soluble Receptor for Advanced Glycation End Products and Coronary Artery Disease in Nondiabetic Men. Arterioscler. Thromb. Vasc. Bio. 25: 1032-1037 [Abstract] [Full Text]  
• Lau, D. C. W., Dhillon, B., Yan, H., Szmitko, P. E., Verma, S. (2005). Adipokines: molecular links between obesity and atheroslcerosis. Am. J. Physiol. Heart Circ. Physiol. 288: H2031-H2041 [Abstract] [Full Text]  
• Mikkelsson, J., Perola, M., Karhunen, P. J. (2005). Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications. CLIN APPL THROMB HEMOST 11: 113-125 [Abstract]  
• Rasul, F, Stansfeld, S A, Hart, C L, Davey Smith, G (2005). Psychological distress, physical illness, and risk of coronary heart disease. J. Epidemiol. Community Health 59: 140-145 [Abstract] [Full Text]  
• Bursi, F., Enriquez-Sarano, M., Nkomo, V. T., Jacobsen, S. J., Weston, S. A., Meverden, R. A., Roger, V. L. (2005). Heart Failure and Death After Myocardial Infarction in the Community: The Emerging Role of Mitral Regurgitation. Circulation 111: 295-301 [Abstract] [Full Text]  
• Grigioni, F., Detaint, D., Avierinos, J.-F., Scott, C., Tajik, J., Enriquez-Sarano, M. (2005). Contribution of ischemic mitral regurgitation to congestive heart failure after myocardial infarction. J Am Coll Cardiol 45: 260-267 [Abstract] [Full Text]  
• Davi, G., Neri, M., Falco, A., Festi, D., Taraborelli, T., Ciabattoni, G., Basili, S., Cuccurullo, F., Patrono, C. (2005). Helicobacter Pylori Infection Causes Persistent Platelet Activation In Vivo Through Enhanced Lipid Peroxidation. Arterioscler. Thromb. Vasc. Bio. 25: 246-251 [Abstract] [Full Text]  
• Hsu, L.-F., Jais, P., Sanders, P., Garrigue, S., Hocini, M., Sacher, F., Takahashi, Y., Rotter, M., Pasquie, J.-L., Scavee, C., Bordachar, P., Clementy, J., Haissaguerre, M. (2004). Catheter Ablation for Atrial Fibrillation in Congestive Heart Failure. NEJM 351: 2373-2383 [Abstract] [Full Text]