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Volume 337:1394-1395 November 6, 1997 Number 19
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Measurement of Urinary Trypsinogen-2 as a Screening Test for Acute Pancreatitis

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 by Steinberg, W.
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 by Kemppainen, E. A.
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To the Editor: In describing their comparison of the urinary trypsinogen-2 dipstick test and the serum amylase assay for the diagnosis of acute pancreatitis, Kemppainen et al. (June 19 issue)1 mention the unsatisfactory sensitivity and specificity of both serum amylase and serum lipase determinations. They compared the measurement of urinary trypsinogen-2 with the serum amylase assay but did not mention whether determining serum lipase levels as well would have increased the sensitivity and specificity of a serum-based diagnosis.2 It is well accepted that serum lipase determinations are superior to those of serum amylase, and I wonder why this factor was . . . [Full Text of this Article]

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