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Previous Volume 337:1429-1434 November 13, 1997 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Most patients with corticotropin-independent Cushing's syndrome have an adrenal adenoma or carcinoma,¹ but a few have bilateral adrenal hyperplasia. Three patients with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia^2,3,4 and two patients with adrenal adenomas^5,6 in whom food stimulated cortisol secretion have been described; the abnormal adrenal tissues in these patients aberrantly overexpressed receptors for gastric inhibitory polypeptide.^6,7 We describe a patient with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia in whom endogenous catecholamines, acting through an ectopic adrenal -adrenergic receptor, stimulated cortisol secretion; the hyperadrenocorticism was inhibited by -blockade.

Case Report

A 56-year-old man presented with a left ileofemoral thrombophlebitis, an . . . [Full Text of this Article]

Methods

Clinical Studies

Assays

-Adrenergic–Receptor Binding and Adenylyl Cyclase Assays

Results

In Vivo Studies

In Vitro Studies

-Adrenergic–Receptor Binding

Adrenal-Membrane Adenylyl Cyclase Activity

Discussion

Source Information

From the Division of Endocrinology and the Department of Medicine, Research Center, Pavillon Hôtel-Dieu, Centre Hospitalier de l'Université de Montréal (A.L., J.T., P.H.), and the Research Group on the Autonomic Nervous System, Department of Biochemistry, Université de Montréal (G.R., M.B.) — both in Montreal.

Address reprint requests to Dr. Lacroix at the Research Center, Pavillon Hôtel-Dieu, CHUM, 3850 St.-Urbain, Montreal, QC H2W 1T8, Canada.

References

This article has been cited by other articles:

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