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Previous Volume 337:1557-1558 November 20, 1997 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by van der Horst, C. M. Related Article by van der Horst, C. M. PubMed Citation

To the Editor: The conclusion of van der Horst et al. (July 3 issue)¹ that the combination regimen of higher-dose amphotericin B plus flucytosine, followed by consolidation therapy with oral fluconazole, is safe and effective and should now be considered the treatment of choice for AIDS-associated cryptococcal meningitis cannot be supported by the study design or the 10-week outcomes. This two-stage design has a significant bias — the healthy-survivor effect — in that only healthy survivors were permitted to enroll in the consolidation phase of the trial. The data analysis does not address the censoring effect of eliminating patients with . . . [Full Text of this Article]

References

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