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Volume 337:1705-1714 December 11, 1997 Number 24 Next

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ABSTRACT

Background Alcohol consumption has both adverse and beneficial effects on survival. We examined the balance of these in a large prospective study of mortality among U.S. adults.

Methods Of 490,000 men and women (mean age, 56 years; range, 30 to 104) who reported their alcohol and tobacco use in 1982, 46,000 died during nine years of follow-up. We compared cause-specific death rates and rates of death from all causes across categories of base-line alcohol consumption, adjusting for other risk factors, and related drinking and smoking habits to the cumulative probability of dying between the ages of 35 and 69 years.

Results Causes of death associated with drinking were cirrhosis and alcoholism; cancers of the mouth, esophagus, pharynx, larynx, and liver combined; breast cancer in women; and injuries and other external causes in men. The mortality from breast cancer was 30 percent higher among women reporting at least one drink daily than among nondrinkers (relative risk, 1.3; 95 percent confidence interval, 1.1 to 1.6). The rates of death from all cardiovascular diseases were 30 to 40 percent lower among men (relative risk, 0.7; 95 percent confidence interval, 0.7 to 0.8) and women (relative risk, 0.6; 95 percent confidence interval, 0.6 to 0.7) reporting at least one drink daily than among nondrinkers, with little relation to the level of consumption. The overall death rates were lowest among men and women reporting about one drink daily. Mortality from all causes increased with heavier drinking, particularly among adults under age 60 with lower risk of cardiovascular disease. Alcohol consumption was associated with a small reduction in the overall risk of death in middle age (ages 35 to 69), whereas smoking approximately doubled this risk.

Conclusions In this middle-aged and elderly population, moderate alcohol consumption slightly reduced overall mortality. The benefit depended in part on age and background cardiovascular risk and was far smaller than the large increase in risk produced by tobacco.

Source Information

From Epidemiology and Surveillance Research, American Cancer Society, Atlanta (M.J.T., J.H.M., S.J.H., C.W.H.); the Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, England (R.P., R.D.); and the Programme on Substance Abuse, World Health Organization, Geneva (A.D.L.).

Address reprint requests to Dr. Thun at Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Rd., NE, Atlanta, GA 30329-4251.

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Alcohol Consumption and Mortality in U.S. Adults
Lowenfels A. B., Urbach D. R., Bell C. M., Thun M. J., Peto R., Heath C. W., Potter J. D.
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N Engl J Med 1998; 338:1385-1386, May 7, 1998. Correspondence

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• Whitlock, E. P., Polen, M. R., Green, C. A., Orleans, T., Klein, J. (2004). Behavioral Counseling Interventions in Primary Care To Reduce Risky/Harmful Alcohol Use by Adults: A Summary of the Evidence for the U.S. Preventive Services Task Force. ANN INTERN MED 140: 557-568 [Abstract] [Full Text]  
• de Lorgeril, M, Salen, P (2004). Is alcohol anti-inflammatory in the context of coronary heart disease?. Heart 90: 355-357 [Abstract] [Full Text]  
• Zairis, M N, Ambrose, J A, Lyras, A G, Thoma, M A, Psarogianni, P K, Psaltiras, P G, Kardoulas, A D, Bibis, G P, Pissimissis, E G, Batika, P C, DeVoe, M C, Prekates, A A, Foussas, S G (2004). C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study. Heart 90: 419-424 [Abstract] [Full Text]  
• Malinski, M. K., Sesso, H. D., Lopez-Jimenez, F., Buring, J. E., Gaziano, J. M. (2004). Alcohol Consumption and Cardiovascular Disease Mortality in Hypertensive Men. Arch Intern Med 164: 623-628 [Abstract] [Full Text]  
• Smith, G. D., Ebrahim, S. (2004). Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33: 30-42 [Full Text]  
• Malyutina, S., Bobak, M., Kurilovitch, S., Nikitin, Y., Marmot, M. (2004). TRENDS IN ALCOHOL INTAKE BY EDUCATION AND MARITAL STATUS IN AN URBAN POPULATION IN RUSSIA BETWEEN THE MID 1980s AND THE MID 1990s. Alcohol Alcohol 39: 64-69 [Abstract] [Full Text]  
• Greenfield, J. R., Samaras, K., Jenkins, A. B., Kelly, P. J., Spector, T. D., Campbell, L. V. (2003). Moderate Alcohol Consumption, Dietary Fat Composition, and Abdominal Obesity in Women: Evidence for Gene-Environment Interaction. J. Clin. Endocrinol. Metab. 88: 5381-5386 [Abstract] [Full Text]  
• Lindahl, B., Stegmayr, B., Johansson, I., Weinehall, L., Hallmans, G. (2003). Trends in lifestyle 1986 - 99 in a 25- to 64-year-old population of the Northern Sweden MONICA project. Scand J Public Health 31: 31-37 [Abstract]  
• Fisher Wilson, J. (2003). Should Doctors Prescribe Alcohol to Adults?. ANN INTERN MED 139: 711-714 [Full Text]  
• Klatsky, A. L., Friedman, G. D., Armstrong, M. A., Kipp, H. (2003). Wine, Liquor, Beer, and Mortality. Am J Epidemiol 158: 585-595 [Abstract] [Full Text]  
• Dorn, J. M., Hovey, K., Muti, P., Freudenheim, J. L., Russell, M., Nochajski, T. H., Trevisan, M. (2003). Alcohol Drinking Patterns Differentially Affect Central Adiposity as Measured by Abdominal Height in Women and Men. J. Nutr. 133: 2655-2662 [Abstract] [Full Text]  
• Peters, U., Askling, J., Gridley, G., Ekbom, A., Linet, M. (2003). Causes of Death in Patients With Celiac Disease in a Population-Based Swedish Cohort. Arch Intern Med 163: 1566-1572 [Abstract] [Full Text]  
• Gupta, P. C., Saxena, S., Pednekar, M. S., Maulik, P. K. (2003). ALCOHOL CONSUMPTION AMONG MIDDLE-AGED AND ELDERLY MEN: A COMMUNITY STUDY FROM WESTERN INDIA. Alcohol Alcohol 38: 327-331 [Abstract] [Full Text]  
• Aronson, K. (2003). Alcohol: a recently identified risk factor for breast cancer. CMAJ 168: 1147-1148 [Full Text]  
• (2002). References. Circulation 106: 3373-3421 [Full Text]  
• John, U., Hanke, M. (2002). ALCOHOL-ATTRIBUTABLE MORTALITY IN A HIGH PER CAPITA CONSUMPTION COUNTRY -- GERMANY. Alcohol Alcohol 37: 581-585 [Abstract] [Full Text]  
• de Lorgeril, M., Salen, P., Martin, J.-L., Boucher, F., Paillard, F., de Leiris, J. (2002). Wine Drinking and Risks of Cardiovascular Complications After Recent Acute Myocardial Infarction. Circulation 106: 1465-1469 [Abstract] [Full Text]  
• Zhou, H.-Z., Karliner, J. S., Gray, M. O. (2002). Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt. Am. J. Physiol. Heart Circ. Physiol. 283: H165-H174 [Abstract] [Full Text]  
• Rimm, E. B., Stampfer, M. J. (2002). Wine, Beer, and Spirits: Are They Really Horses of a Different Color?. Circulation 105: 2806-2807 [Full Text]  
• Kahana, E., Lawrence, R. H., Kahana, B., Kercher, K., Wisniewski, A., Stoller, E., Tobin, J., Stange, K. (2002). Long-Term Impact of Preventive Proactivity on Quality of Life of the Old-Old. Psychosom. Med. 64: 382-394 [Abstract] [Full Text]  
• Jousilahti, P., Vartiainen, E., Alho, H., Poikolainen, K., Sillanaukee, P. (2002). Opposite Associations of Carbohydrate-Deficient Transferrin and {gamma}-Glutamyltransferase With Prevalent Coronary Heart Disease. Arch Intern Med 162: 817-821 [Abstract] [Full Text]  
• Korte, J. E., Brennan, P., Henley, S. J., Boffetta, P. (2002). Dose-specific Meta-Analysis and Sensitivity Analysis of the Relation between Alcohol Consumption and Lung Cancer Risk. Am J Epidemiol 155: 496-506 [Abstract] [Full Text]  
• Kromhout, D., Menotti, A., Kesteloot, H., Sans, S. (2002). Prevention of Coronary Heart Disease by Diet and Lifestyle: Evidence From Prospective Cross-Cultural, Cohort, and Intervention Studies. Circulation 105: 893-898 [Full Text]  
• Walsh, C. R., Larson, M. G., Evans, J. C., Djousse, L., Ellison, R. C., Vasan, R. S., Levy, D. (2002). Alcohol Consumption and Risk for Congestive Heart Failure in the Framingham Heart Study. ANN INTERN MED 136: 181-191 [Abstract] [Full Text]  
• Lorenzo, C., Serrano-Rios, M., Martinez-Larrad, M. T., Gabriel, R., Williams, K., Gonzalez-Villalpando, C., Stern, M. P., Hazuda, H. P., Haffner, S. (2002). Prevalence of Hypertension in Hispanic and non-Hispanic White Populations. Hypertension 39: 203-208 [Abstract] [Full Text]  
• Wannamethee, S G, Shaper, A G (2002). Taking up regular drinking in middle age: effect on major coronary heart disease events and mortality. Heart 87: 32-36 [Abstract] [Full Text]  
• Ferner, R E, Chambers, J. (2001). Alcohol intake: measure for measure. BMJ 323: 1439-1440 [Full Text]  
• Tanasescu, M., Hu, F. B., Willett, W. C., Stampfer, M. J., Rimm, E. B. (2001). Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus. J Am Coll Cardiol 38: 1836-1842 [Abstract] [Full Text]  
• Singletary, K. W., Gapstur, S. M. (2001). Alcohol and Breast Cancer: Review of Epidemiologic and Experimental Evidence and Potential Mechanisms. JAMA 286: 2143-2151 [Abstract] [Full Text]