The hepatitis B virus (HBV), discovered in 1966, infects morethan 350 million people worldwide.1 Hepatitis B is a leadingcause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma,accounting for 1 million deaths annually. Knowledge of the intricaciesof viral infection and of the molecular biology of this fascinatingvirus has led to the successful development of a vaccine andto treatment sometimes capable of eradicating chronic infection.This review addresses many aspects of HBV infection, includingthe role of the immune system in determining the outcome ofclinical infection, recent developments in molecular studiesof the virus, and new . . . [Full Text of this Article]
Historical Background
Epidemiology
Virologic Characteristics
Immunopathogenesis
Life Cycle of HBV in the Human Host
Associated Clinical Syndromes
Hepatitis D
Hepatitis C
Human Immunodeficiency Virus Infection
Fulminant Hepatitis B
Hepatitis B after Liver Transplantation
Infection with Mutant Viruses
Extrahepatic Diseases
Hepatocellular Carcinoma
Natural History and Treatment of Hepatitis B
Interferon Therapy
Treatment for Special Groups
Patients with Decompensated Cirrhosis
Patients with Hdv Superinfection
Patients with Mutant Viruses
Nucleoside Analogues
Hepatitis B Vaccine
Source Information
From the Liver Division, Department of Internal Medicine, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75235-9151, where reprint requests should be addressed to Dr. Lee.
References
Related Letters:
Hepatitis B Virus Infection
Ortiz A., de Sequera P., Carreño V., Caramelo C., Abramowicz D., Blanpain C., Knoop C., Koblin B. A., Taylor P. E., Stevens C. E., Chen P.-J., Chen D.-S., Lee W. M.
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N Engl J Med 1998;
338:1311-1313, Apr 30, 1998.
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