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Previous Volume 337:195-197 July 17, 1997 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Only a few years ago, little was known about the role of cytokines in rheumatoid arthritis. The original view of the cytokine milieu in the inflamed joint as a melange of factors from various cells was clarified by two observations.¹ First, in inflammation of rheumatoid arthritis, cytokines from macrophages and fibroblasts dominate, and second, the cytokine profile within the macrophage and fibroblast reflects a hierarchy, with interleukin-1 and tumor necrosis factor (TNF-) assuming particular importance. Anticytokine therapy for rheumatoid arthritis has now reached the clinic, and the report in this issue of the Journal by Moreland et al.² adds . . . [Full Text of this Article]

References

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• Deon, D., Ahmed, S., Tai, K., Scaletta, N., Herrero, C., Lee, I.-H., Krause, A., Ivashkiv, L. B. (2001). Cross-Talk Between IL-1 and IL-6 Signaling Pathways in Rheumatoid Arthritis Synovial Fibroblasts. J. Immunol. 167: 5395-5403 [Abstract] [Full Text]  
• Schattner, A. (2000). A new era in rheumatoid arthritis treatment--time to introduce a modified treatment pyramid. QJM 93: 757-760 [Full Text]  
• Li, P., Sanz, I., O'Keefe, R. J., Schwarz, E. M. (2000). NF-{kappa}B Regulates VCAM-1 Expression on Fibroblast-Like Synoviocytes. J. Immunol. 164: 5990-5997 [Abstract] [Full Text]  
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• O'Brien, D. P., Briles, D. E., Szalai, A. J., Tu, A.-H., Sanz, I., Nahm, M. H. (1999). Tumor Necrosis Factor Alpha Receptor I Is Important for Survival from Streptococcus pneumoniae Infections. Infect. Immun. 67: 595-601 [Abstract] [Full Text]  
• Brooks, P. (1998). Recent advances: Rheumatology. BMJ 316: 1810-1812 [Full Text]