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Editorial
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Volume 337:197-198 July 17, 1997 Number 3
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Autoantibodies and Pregnancy Loss

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Two articles in this issue of the Journal1,2 focus on autoantibodies as a cause of pregnancy loss. Rand and coworkers describe a mechanism by which antiphospholipid antibodies could cause placental thrombosis and infarction. They found that antiphospholipid antibodies lower levels of annexin V, a surface anticoagulant present in cultured vascular and trophoblast cells that has a high affinity for anionic phospholipids; by this mechanism, the time to fibrin formation is reduced when plasma is incubated with cells previously incubated with antiphospholipid antibody.1 Laskin and coworkers report the results of a randomized trial of the efficacy of prednisone treatment with respect . . . [Full Text of this Article]

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