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A correction has been published: N Engl J Med 1998;338(8):555.

Previous Volume 337:396-407 August 7, 1997 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Obesity is the most common and costly nutritional problem in the United States, affecting approximately 33 percent of adults.¹ Health care costs directly attributable to obesity amount to approximately $68 billion per year, and an additional $30 billion per year is spent on weight-reduction programs and special foods.² Nevertheless, treatment directed toward the long-term reduction of body weight is largely ineffective, and 90 to 95 percent of persons who lose weight subsequently regain it.^3,4

The level of energy storage, or fatness, at which the risk of morbidity increases is determined on an actuarial basis. The body-mass index (the weight in . . . [Full Text of this Article]

Regulation of Energy Storage, Intake, and Expenditure

Neurophysiology of Feeding

Metabolic Effects of Weight Perturbation

Futile Cycles

Chemical Mediators of Energy Homeostasis

Insulin

Cholecystokinin

Other Endocrine and Peptide Signals

Leptin

Leptin Receptors

Neuropeptide Y

Genetic Factors

Treatment

Lifestyle Modification

            The Role of Dietary Composition

            The Role of Exercise

            The Role of Behavior Modification

Drug Therapy

Surgical Therapy

Conclusions

Source Information

From the Laboratory of Human Behavior and Metabolism, Rockefeller University, 1230 York Ave., New York, NY 10021, where reprint requests should be addressed to Dr. Hirsch.

References

Related Letters:

Obesity
Seaton T. B., Mendel C. M., Weinstein S. P., Eisenbud E., Hirsch J., Leibel R. L., Rosenbaum M.
Extract | Full Text  
N Engl J Med 1998; 338:64-65, Jan 1, 1998. Correspondence

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