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Correspondence
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Volume 337:422-424 August 7, 1997 Number 6
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease

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 by Ridker, P. M.
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To the Editor: Ridker and colleagues (April 3 issue)1 have provided important new information that will be useful in assessing the risk of cardiovascular events and in optimizing prophylaxis. Both Ridker et al. and Maseri, in his editorial,2 speculate that the antiinflammatory effects of aspirin may be important in reducing the risk of myocardial infarction when the level of C-reactive protein is high.

It seems unlikely that the antiinflammatory effects of aspirin have an important role, since these effects are minuscule and short-lived at the dosage used in the study by Ridker et al. (325 mg every other day). Were . . . [Full Text of this Article]

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