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Previous Volume 337:428-429 August 7, 1997 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Several comments are in order for the U.S. audience of the excellent review of osteomyelitis by Lew and Waldvogel (April 3 issue),¹ especially regarding Table 2. Many infectious-disease specialists prescribe both penicillin and nafcillin every four hours, rather than every six hours as suggested in the article. These beta-lactams have a short half-life, and consideration should certainly be given to using the higher dose (i.e., a shorter interval between doses). Clindamycin can be given effectively every eight hours because of its prolonged half-life. No clinical advantage has ever been proved for the administration of 600 mg every . . . [Full Text of this Article]

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