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Over the past 20 years, considerable advances have been made toward understanding the cause of rheumatoid arthritis, the mechanisms of joint destruction, the timing of events conducive to such an outcome, subgroups of patients with different possible outcomes, rational therapeutic strategies, and the effects of this disease on patients, families, and society. Gains have been made in recognizing the contribution of genetic and socioeconomic factors to the course and outcome of rheumatoid arthritis, early treatment strategies, and most important, preventive measures. Knowledge is being generated at an incredible pace, and we seem to be close to the elucidation of not
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