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Previous Volume 337:570-572 August 21, 1997 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Rabkin et al. (April 3 issue)¹ studied multiple biopsy specimens from eight patients with Kaposi's sarcoma and claim that Kaposi's sarcoma begins as a clonal disease at some specific site, circulates in the blood, and implants itself at multiple sites in the skin to produce multicentric disease. The unbalanced methylation pattern at the androgen-receptor locus in Kaposi's sarcoma lesions provides the evidence for their view.

We are concerned about some of the authors' technical procedures. They do not provide results of amplification by the polymerase chain reaction with androgen-receptor primers and undigested DNA, to ensure that the . . . [Full Text of this Article]

References

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• Duprez, R., Lacoste, V., Briere, J., Couppie, P., Frances, C., Sainte-Marie, D., Kassa-Kelembho, E., Lando, M.-J., Essame Oyono, J.-L., Nkegoum, B., Hbid, O., Mahe, A., Lebbe, C., Tortevoye, P., Huerre, M., Gessain, A. (2007). Evidence for a Multiclonal Origin of Multicentric Advanced Lesions of Kaposi Sarcoma. JNCI J Natl Cancer Inst 99: 1086-1094 [Abstract] [Full Text]  
• Malatos, S., Neubert, H., Kicman, A. T., Iles, R. K. (2005). Identification of Placental Transforming Growth Factor-{beta} and Bikunin Metabolites as Contaminants of Pharmaceutical Human Chorionic Gonadotrophin Preparations by Proteomic Techniques. Mol. Cell. Proteomics 4: 984-992 [Abstract] [Full Text]  
• Butler, S. A., Iles, R. K. (2003). Ectopic Human Chorionic Gonadotropin {beta} Secretion by Epithelial Tumors and Human Chorionic Gonadotropin {beta}-Induced Apoptosis in Kaposi's Sarcoma: Is There a Connection?. Clin. Cancer Res. 9: 4666-4673 [Abstract] [Full Text]  
• Barillari, G., Ensoli, B. (2002). Angiogenic Effects of Extracellular Human Immunodeficiency Virus Type 1 Tat Protein and Its Role in the Pathogenesis of AIDS-Associated Kaposi's Sarcoma. Clin. Microbiol. Rev. 15: 310-326 [Abstract] [Full Text]  
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• Moore, P. S., Chang, Y. (1998). Kaposi's Sarcoma-Associated Herpesvirus-Encoded Oncogenes and Oncogenesis. J Natl Cancer Inst Monogr 1998: 65-71 [Abstract] [Full Text]