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Previous Volume 337:629-630 August 28, 1997 Number 9 Next

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Between 1967 and 1972, there was a serious outbreak of primary pulmonary hypertension in Western Europe.¹ The incidence of the disorder among patients seen at major cardiac catheterization centers in Switzerland, Germany, and Austria increased by a factor of 10. This unusual epidemic was traced to the use of an appetite-suppressant drug, aminorex (Menocil), which had been introduced in Europe shortly before. The drug was quickly withdrawn from the market, but not before it had resulted in substantial morbidity and a mortality rate of 50 percent among affected patients. Postmortem examinations in fatal cases disclosed obstructive lesions in the muscular . . . [Full Text of this Article]

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Extract | Full Text  
N Engl J Med 1997; 337:1772-1776, Dec 11, 1997. Correspondence

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