Case 21-1997: Paraneoplastic Cerebellar Degeneration and Hodgkin's Disease

doi:10.1056/NEJM199801013380116

Volume 338:66		January 1, 1998		Number 1

Case 21-1997: Paraneoplastic Cerebellar Degeneration and Hodgkin's Disease

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To the Editor: Dr. Eder, in his discussion of the paraneoplasticcerebellar degeneration associated with Hodgkin's disease (July10 issue),¹ quoted the 1976 paper by Trotter and colleagues²but did not mention that the antibodies they described are nowrecognized as distinct antibodies associated with Hodgkin'sdisease. These antibodies have been designated anti-Tr antibodies.³They have a characteristic dotted staining pattern, suggestiveof immunoreactivity of the dendritic spines of Purkinje cells,and are specific for Hodgkin's disease.

Tahseen Mozaffar, M.B., B.S.
Aga Khan University College ofMedicine
Karachi 74800, Pakistan

References

Case Records of the Massachusetts General Hospital (Case 21-1997). N Engl J Med 1997;337:115-122. [Free Full Text]
Trotter JL, Hendin BA, Osterland CK. Cerebellar degeneration with Hodgkin disease: an immunological study. Arch Neurol 1976;33:660-661. [Free Full Text]
Graus F, Dalmau J, Valldeoriola F, et al. Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. J Neuroimmunol 1997;74:55-61. [CrossRef][Medline]