Preeclampsia, defined as hypertension and proteinuria or nondependentedema after 20 weeks' gestation, is a common complication ofpregnancy. Endothelial-cell dysfunction with vasospasm, pathologiccoagulation, and hypersensitivity to pressor substances furthercharacterize the disorder. When severe, preeclampsia can causerenal failure, hepatic dysfunction, cardiac and pulmonary failure,seizures, and death.
Despite more than half a century of intensive research, preeclampsiacontinues to be a major contributor to maternal and perinatalmortality. Where access to prenatal care and hospital resourcesis limited, morbidity and mortality rates for both mothers andbabies are high. It is therefore not hard to understand the. . . [Full Text of this Article]
References
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