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Previous Volume 338:763-765 March 12, 1998 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Marafioti et al. (Aug. 14 issue)¹ report on monoclonal populations of lymphocytic and histiocytic (L&H) cells harboring somatically mutated genes of the antibody V_H region in 11 cases of lymphocyte-predominant Hodgkin's disease. On the basis of the high load of somatic mutations and signs of ongoing mutations, the authors conclude that L&H cells are resistant to normal selection processes, perhaps because of a block in the apoptotic pathway, and that "the presence in two patients of L&H cells with disrupted capacity for coding by immunoglobulin genes supports this theory, because normally such B cells cannot survive." Marafioti . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Renne, C., Martin-Subero, J. I., Hansmann, M.-L., Siebert, R. (2005). Molecular Cytogenetic Analyses of Immunoglobulin Loci in Nodular Lymphocyte Predominant Hodgkin's Lymphoma Reveal a Recurrent IGH-BCL6 Juxtaposition. J. Mol. Diagn. 7: 352-356 [Abstract] [Full Text]  
• Brauninger, A., Wacker, H.-H., Rajewsky, K., Kuppers, R., Hansmann, M.-L. (2003). Typing the Histogenetic Origin of the Tumor Cells of Lymphocyte-rich Classical Hodgkin's Lymphoma in Relation to Tumor Cells of Classical and Lymphocyte-predominance Hodgkin's Lymphoma. Cancer Res. 63: 1644-1651 [Abstract] [Full Text]  
• Brauninger, A., Kuppers, R., Spieker, T., Siebert, R., Strickler, J. G., Schlegelberger, B., Rajewsky, K., Hansmann, M.-L. (1999). Molecular Analysis of Single B Cells From T-Cell-Rich B-Cell Lymphoma Shows the Derivation of the Tumor Cells From Mutating Germinal Center B Cells and Exemplifies Means by Which Immunoglobulin Genes Are Modified in Germinal Center B Cells. Blood 93: 2679-2687 [Abstract] [Full Text]