Molecular Analysis of the Progression from Helicobacter pyloriAssociated Chronic Gastritis to Mucosa-Associated Lymphoid-Tissue Lymphoma of the Stomach
Emanuele Zucca, M.D., Francesco Bertoni, M.D., Enrico Roggero, M.D., Giovanna Bosshard, Giovanni Cazzaniga, B.Sc., Ennio Pedrinis, M.D., Andrea Biondi, M.D., and Franco Cavalli, M.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Several lines of evidence suggest a link between chronic gastritisdue to Helicobacter pylori and mucosa-associated lymphoid-tissue(MALT) lymphoma of the stomach.1,2 A close epidemiologic associationhas been reported.3,4,5 The microorganism can be found in thegastric mucosa in nearly all cases, and regression of low-gradegastric MALT lymphoma has been demonstrated after the eradicationof H. pylori.6,7
The suggested progression from H. pyloriassociated chronicgastritis to overt MALT lymphoma8 has not been formally demonstrated,although if it exists, such a mechanism may have important implicationsfor the treatment of H. pyloriassociated gastritis. EachB cell contains immunoglobulin . . . [Full Text of this Article]
Case Reports
Patient 1
Patient 2
Methods
Histologic Analysis
Consensus-Sequence PCR
Cloning and Sequencing of PCR Products
Allele-Specific PCR
Results
Patient 1
Patient 2
Discussion
Source Information
From the Servizio Oncologico Cantonale, Ospedale San Giovanni, Bellinzona, Switzerland (E.Z., F.B., E.R., G.B., F.C.); Clinica Pediatrica dell'Università di Milano, Ospedale San Gerardo, Monza, Italy (G.C., A.B.); and Istituto Cantonale di Patologia, Locarno, Switzerland (E.P.).
Address reprint requests to Dr. Cavalli at the Servizio Oncologico Cantonale, Ospedale San Giovanni, 6500 Bellinzona, Switzerland.
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