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Original Article
Brief Report
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Volume 338:804-810 March 19, 1998 Number 12
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Molecular Analysis of the Progression from Helicobacter pylori–Associated Chronic Gastritis to Mucosa-Associated Lymphoid-Tissue Lymphoma of the Stomach
Emanuele Zucca, M.D., Francesco Bertoni, M.D., Enrico Roggero, M.D., Giovanna Bosshard, Giovanni Cazzaniga, B.Sc., Ennio Pedrinis, M.D., Andrea Biondi, M.D., and Franco Cavalli, M.D.

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Several lines of evidence suggest a link between chronic gastritis due to Helicobacter pylori and mucosa-associated lymphoid-tissue (MALT) lymphoma of the stomach.1,2 A close epidemiologic association has been reported.3,4,5 The microorganism can be found in the gastric mucosa in nearly all cases, and regression of low-grade gastric MALT lymphoma has been demonstrated after the eradication of H. pylori.6,7

The suggested progression from H. pylori–associated chronic gastritis to overt MALT lymphoma8 has not been formally demonstrated, although if it exists, such a mechanism may have important implications for the treatment of H. pylori–associated gastritis. Each B cell contains immunoglobulin . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Methods

Histologic Analysis

Consensus-Sequence PCR

Cloning and Sequencing of PCR Products

Allele-Specific PCR

Results

Patient 1

Patient 2

Discussion


Source Information

From the Servizio Oncologico Cantonale, Ospedale San Giovanni, Bellinzona, Switzerland (E.Z., F.B., E.R., G.B., F.C.); Clinica Pediatrica dell'Università di Milano, Ospedale San Gerardo, Monza, Italy (G.C., A.B.); and Istituto Cantonale di Patologia, Locarno, Switzerland (E.P.).

Address reprint requests to Dr. Cavalli at the Servizio Oncologico Cantonale, Ospedale San Giovanni, 6500 Bellinzona, Switzerland.

References


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